CP-154,526

CP-154,526 is a potent and selective antagonist of the corticotropin releasing hormone receptor 1 developed by Pfizer.^[1]

CP-154,526

Names
Preferred IUPAC name N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[3,2-e]pyrimidin-4-amine
Identifiers
CAS Number	157286-86-7 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL9946 N
ChemSpider	4470592 N
IUPHAR/BPS	3495
PubChem CID	5311055
UNII	9A549FB00R Y
CompTox Dashboard (EPA)	DTXSID201027582
InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 N Key: FHQYJZCJRZHINA-UHFFFAOYSA-N N InChI=1/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 Key: FHQYJZCJRZHINA-UHFFFAOYAW
SMILES CCCCN(CC)C1=NC(=NC2=C1C(=CN2C3=C(C=C(C=C3C)C)C)C)C
Properties
Chemical formula	C23H32N4
Molar mass	364.52698
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

CP-154,526 is under investigation for the potential treatment of alcoholism.^[2][3]

See also

• Antalarmin
• Pexacerfont
• Corticotropin releasing hormone antagonist

References

1. Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD, Winston EN, Chen YL, Heym J (September 1996). "CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (19): 10477–82. Bibcode:1996PNAS...9310477S. doi:10.1073/pnas.93.19.10477. PMC 38410. PMID 8816826.
2. "Drug Has Potential To Prevent Alcoholics From Relapsing". Science News. ScienceDaily. 2008-08-02. Retrieved 2008-08-09.
3. Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ (July 2008). "Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism". Proceedings of the National Academy of Sciences of the United States of America. 105 (26): 9070–5. Bibcode:2008PNAS..105.9070P. doi:10.1073/pnas.0710181105. PMC 2449366. PMID 18591672.

Further reading

• Seymour PA, Schmidt AW, Schulz DW (2006). "The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review". CNS Drug Reviews. 9 (1): 57–96. doi:10.1111/j.1527-3458.2003.tb00244.x. PMC 6741649. PMID 12595912.
• Navarro-Zaragoza J, Núñez C, Laorden ML, Milanés MV (May 2010). "Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal". Molecular Pharmacology. 77 (5): 864–73. doi:10.1124/mol.109.062463. PMID 20159948. S2CID 18588298.
• Kobayashi T, Kiyokawa Y, Takeuchi Y, Mori Y (September 2011). "Pretreatment with CP-154526 blocks the modifying effects of alarm pheromone on components of sexual behavior in male, but not in female, rats". Chemical Senses. 36 (7): 623–32. doi:10.1093/chemse/bjr017. PMID 21502338.

External links

• CP+154526 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)