CNTNAP4

Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene.^[5][6]

CNTNAP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NXQ
Identifiers
Aliases	CNTNAP4, CASPR4, contactin associated protein like 4, contactin associated protein family member 4
External IDs	OMIM: 610518; MGI: 2183572; HomoloGene: 24912; GeneCards: CNTNAP4; OMA:CNTNAP4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q23.1 Start 76,277,278 bp[1] End 76,560,757 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 113,296,675 bp[2] End 113,609,349 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment corpus callosum endothelial cell inferior ganglion of vagus nerve pons substantia nigra subthalamic nucleus medulla oblongata hypothalamus cerebellar hemisphere Top expressed in substantia nigra ventral tegmental area pontine nuclei central gray substance of midbrain dorsomedial hypothalamic nucleus cerebellar cortex habenula trigeminal ganglion retinal pigment epithelium lobe of cerebellum More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane cell junction plasma membrane dendrite synapse presynaptic membrane membrane GABA-ergic synapse integral component of presynaptic membrane Biological process regulation of synaptic transmission, dopaminergic regulation of grooming behavior cell adhesion regulation of synaptic transmission, GABAergic regulation of synapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85445 170571 Ensembl ENSG00000152910 ENSMUSG00000031772 UniProt Q9C0A0 Q99P47 RefSeq (mRNA) NM_033401 NM_138994 NM_001322178 NM_001322179 NM_001322180 NM_001322181 NM_001322187 NM_001322188 NM_001322189 NM_001322190 NM_001322191 NM_130457 RefSeq (protein) NP_001309107 NP_001309108 NP_001309109 NP_001309110 NP_001309116 NP_001309117 NP_001309118 NP_001309119 NP_001309120 NP_207837 NP_620481 NP_569724 Location (UCSC) Chr 16: 76.28 – 76.56 Mb Chr 8: 113.3 – 113.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000152910 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031772 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E (Jul 2002). "Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains". Mol Cell Neurosci. 20 (2): 283–97. doi:10.1006/mcne.2002.1110. PMID 12093160. S2CID 25024421.
6. "Entrez Gene: CNTNAP4 contactin associated protein-like 4".

External links

• Human CNTNAP4 genome location and CNTNAP4 gene details page in the UCSC Genome Browser.

Further reading

• Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags". DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID 17213182.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.