CMA1

For the November 2016 UNFCCC COP 22/CMP 12/CMA 1 meeting in Marrakech, see 2016 United Nations Climate Change Conference.

Chymase is an enzyme that in humans is encoded by the CMA1 gene.^[5]

CMA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3S0N, 1NN6, 4AFS, 1PJP, 1T31, 2HVX, 3N7O, 4AG1, 4K69, 4KP0, 1KLT, 4AFZ, 4AG2, 4K2Y, 4K60, 4AFU, 4K5Z, 4AFQ
Identifiers
Aliases	CMA1, CYH, MCT1, chymase, chymase 1
External IDs	OMIM: 118938; MGI: 96941; HomoloGene: 55606; GeneCards: CMA1; OMA:CMA1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,505,353 bp[1] End 24,508,265 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 56,178,908 bp[2] End 56,182,132 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gallbladder skin of hip rectum skin of limb skin of leg skin of abdomen subcutaneous adipose tissue epithelium of colon mucosa of transverse colon Top expressed in dermis umbilical cord lip tunica adventitia of aorta ankle tongue skin of abdomen skin of back skin of external ear intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide binding peptidase activity serine-type endopeptidase activity hydrolase activity serine-type peptidase activity endopeptidase activity Cellular component extracellular matrix secretory granule extracellular region extracellular space cytoplasm collagen-containing extracellular matrix Biological process peptide metabolic process angiotensin maturation proteolysis positive regulation of angiogenesis regulation of inflammatory response midbrain development cellular response to glucose stimulus extracellular matrix disassembly basement membrane disassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1215 17228 Ensembl ENSG00000092009 ENSMUSG00000022225 UniProt P23946 P21844 RefSeq (mRNA) NM_001308083 NM_001836 NM_010780 RefSeq (protein) NP_001295012 NP_001827 NP_034910 Location (UCSC) Chr 14: 24.51 – 24.51 Mb Chr 14: 56.18 – 56.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases.^[6]