CLDN17

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene.^[5][6] It belongs to the group of claudins; claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function.^[7] It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules.^[8][9]

CLDN17
Identifiers
Aliases	CLDN17, claudin 17
External IDs	OMIM: 617005; MGI: 2652030; HomoloGene: 8116; GeneCards: CLDN17; OMA:CLDN17 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 30,165,565 bp[1] End 30,166,805 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 88,302,695 bp[2] End 88,303,866 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle cervix epithelium oral cavity human penis epithelium of esophagus gums vagina body of tongue vulva gingival epithelium Top expressed in esophagus embryo ear surface ectoderm nose pharyngeal arch lip stomach zone of skin visual system More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding chloride channel activity protein binding Cellular component integral component of membrane cell junction plasma membrane membrane bicellular tight junction chloride channel complex Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ion transport chloride transport chloride transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26285 239931 Ensembl ENSG00000156282 ENSMUSG00000055811 UniProt P56750 Q8BXA6 RefSeq (mRNA) NM_012131 NM_181490 RefSeq (protein) NP_036263 NP_852467 Location (UCSC) Chr 21: 30.17 – 30.17 Mb Chr 16: 88.3 – 88.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000156282 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055811 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh M, Katoh M (May 2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int J Mol Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
6. "Entrez Gene: CLDN17 claudin 17".
7. Adil, MS; Narayanan, SP; Somanath, PR (2021). "Cell-cell junctions: structure and regulation in physiology and pathology". Tissue Barriers. 9 (1): 1848212. doi:10.1080/21688370.2020.1848212. PMC 7849786. PMID 33300427.
8. Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012). "Claudin-17 forms tight junction channels with distinct anion selectivity". Cell Mol Life Sci. 69 (16): 2765–78. doi:10.1007/s00018-012-0949-x. PMC 11115135. PMID 22402829. S2CID 18173604.
9. Adil, M; Parvathagiri, V; Verma, A; Liu, F; Rudraraju, M; Narayanan, SP; Somanath, PR (2022). "Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress". Cells. 11 (11): 1782. doi:10.3390/cells11111782. PMC 9180152. PMID 35681477.

External links

• Human CLDN17 genome location and CLDN17 gene details page in the UCSC Genome Browser.

Further reading

• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes". Eur. J. Cell Biol. 81 (5): 253–63. doi:10.1078/0171-9335-00244. PMID 12067061.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.