CHMP6

Charged multivesicular body protein 6 is a protein that in humans is encoded by the CHMP6 gene.^[5][6][7] It is one of charged multivesicular body proteins and a part of endosomal sorting complexes required for transport-III (ESCRT-III) complex.

CHMP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K3W, 3HTU
Identifiers
Aliases	CHMP6, VPS20, charged multivesicular body protein 6
External IDs	OMIM: 610901; MGI: 3583942; HomoloGene: 11607; GeneCards: CHMP6; OMA:CHMP6 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 80,991,598 bp[1] End 81,009,517 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 119,804,267 bp[2] End 119,810,374 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle muscle of thigh mucosa of transverse colon monocyte granulocyte right lobe of liver sural nerve stromal cell of endometrium ectocervix Top expressed in right kidney saccule otic vesicle yolk sac otic placode spermatocyte proximal tubule duodenum human kidney lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding protein binding protein-containing complex binding Cellular component ESCRT III complex cytosol endosome membrane late endosome membrane endosome membrane extracellular exosome endomembrane system Biological process viral life cycle nucleus organization regulation of exosomal secretion multivesicular body assembly ESCRT III complex assembly endosomal transport protein transport septum digestion after cytokinesis mitotic metaphase plate congression vacuolar transport macroautophagy negative regulation of epidermal growth factor-activated receptor activity transport regulation of protein catabolic process midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79643 208092 Ensembl ENSG00000176108 ENSMUSG00000025371 UniProt Q96FZ7 P0C0A3 RefSeq (mRNA) NM_024591 NM_001085498 RefSeq (protein) NP_078867 NP_001078967 Location (UCSC) Chr 17: 80.99 – 81.01 Mb Chr 11: 119.8 – 119.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Multivesicular body

References

1. GRCh38: Ensembl release 89: ENSG00000176108 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025371 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.
6. Yorikawa C, Shibata H, Waguri S, Hatta K, Horii M, Katoh K, Kobayashi T, Uchiyama Y, Maki M (Mar 2005). "Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting". Biochem J. 387 (Pt 1): 17–26. doi:10.1042/BJ20041227. PMC 1134928. PMID 15511219.
7. "CHMP6 charged multivesicular body protein 6 [ Homo sapiens (human) ]".

External links

• Human CHMP6 genome location and CHMP6 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.