CEP135

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene.^[5][6][7] It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material.^[8] CEP135 is required for the centriolar localization of CEP250.^[9]

CEP135
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FCN
Identifiers
Aliases	CEP135, CEP4, KIAA0635, MCPH8, centrosomal protein 135
External IDs	OMIM: 611423; MGI: 2681869; HomoloGene: 45709; GeneCards: CEP135; OMA:CEP135 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q12 Start 55,948,871 bp[1] End 56,033,361 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.3 Start 76,736,545 bp[2] End 76,794,313 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid buccal mucosa cell sperm ventricular zone testicle gonad bone marrow monocyte Achilles tendon secondary oocyte Top expressed in zygote genital tubercle tail of embryo secondary oocyte spermatid spermatocyte granulocyte ventricular zone primary oocyte epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein C-terminus binding protein binding Cellular component cytoplasm centriole cytosol centrosome cytoskeleton Biological process centriole replication centriole-centriole cohesion G2/M transition of mitotic cell cycle positive regulation of non-motile cilium assembly ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle positive regulation of establishment of protein localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9662 381644 Ensembl ENSG00000174799 ENSMUSG00000036403 UniProt Q66GS9 Q6P5D4 RefSeq (mRNA) NM_014645 NM_025009 NM_199032 RefSeq (protein) NP_079285 NP_950197 Location (UCSC) Chr 4: 55.95 – 56.03 Mb Chr 5: 76.74 – 76.79 Mb PubMed search [3] [4]
Wikidata
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