CELSR2

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.^[5][6]

CELSR2
Identifiers
Aliases	CELSR2, CDHF10, EGFL2, Flamingo1, MEGF3, ADGRC2, cadherin EGF LAG seven-pass G-type receptor 2
External IDs	OMIM: 604265; MGI: 1858235; HomoloGene: 1078; GeneCards: CELSR2; OMA:CELSR2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,249,539 bp[1] End 109,275,751 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F3|3 47.02 cM Start 108,298,167 bp[2] End 108,323,383 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right frontal lobe prefrontal cortex primary visual cortex hippocampus proper postcentral gyrus C1 segment Brodmann area 9 superior frontal gyrus Top expressed in superior surface of tongue gallbladder lip subiculum superior frontal gyrus visual cortex motor neuron ascending aorta primary visual cortex extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity calcium ion binding transmembrane signaling receptor activity Cellular component integral component of membrane plasma membrane membrane cytoplasm Biological process homophilic cell adhesion via plasma membrane adhesion molecules regulation of transcription, DNA-templated cell surface receptor signaling pathway multicellular organism development regulation of cell-cell adhesion Wnt signaling pathway, planar cell polarity pathway G protein-coupled receptor signaling pathway signal transduction neural plate anterior/posterior regionalization Wnt signaling pathway cell adhesion dendrite morphogenesis cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1952 53883 Ensembl ENSG00000143126 ENSMUSG00000068740 UniProt Q9HCU4 Q9R0M0 RefSeq (mRNA) NM_001408 NM_001004177 NM_017392 RefSeq (protein) NP_001399 NP_001004177 NP_059088 Location (UCSC) Chr 1: 109.25 – 109.28 Mb Chr 3: 108.3 – 108.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.^[6]

See also

• Flamingo (protein)

References

1. GRCh38: Ensembl release 89: ENSG00000143126 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068740 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
6. "Entrez Gene: CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
• Vincent JB, Skaug J, Scherer SW (2001). "The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1". DNA Res. 7 (3): 233–5. doi:10.1093/dnares/7.3.233. PMID 10907856.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

External links

• Human CELSR2 genome location and CELSR2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.