CEACAM3

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a member of the carcinoembryonic antigen (CEA) gene family..^[3]

CEACAM3
Identifiers
Aliases	CEACAM3, CD66D, CEA, CGM1, W264, W282, carcinoembryonic antigen related cell adhesion molecule 3, CEA cell adhesion molecule 3
External IDs	OMIM: 609142; HomoloGene: 130497; GeneCards: CEACAM3; OMA:CEACAM3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 41,796,587 bp[1] End 41,811,554 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte bone marrow bone marrow cells periodontal fiber monocyte spleen mucosa of transverse colon trabecular bone cecum n/a More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 1084 n/a Ensembl ENSG00000170956 n/a UniProt P40198 n/a RefSeq (mRNA) NM_001277163 NM_001815 n/a RefSeq (protein) NP_001264092 NP_001806 n/a Location (UCSC) Chr 19: 41.8 – 41.81 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[3]

Use

CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.^[4]

See also

• Cluster of differentiation