CDH3 (gene)

Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.^[5][6]

CDH3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OY9
Identifiers
Aliases	CDH3, CDHP, HJMD, PCAD, cadherin 3
External IDs	OMIM: 114021; MGI: 88356; HomoloGene: 20425; GeneCards: CDH3; OMA:CDH3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 68,636,189 bp[1] End 68,727,468 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.16 cM Start 107,237,523 bp[2] End 107,283,929 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte lactiferous duct gingival epithelium olfactory zone of nasal mucosa left ovary retinal pigment epithelium nasal epithelium periodontal fiber right ovary hair follicle Top expressed in decidua gastrula choroid plexus of fourth ventricle genital tubercle tail of embryo lip otic vesicle saccule secondary oocyte molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding molecular function cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component cytoplasm integral component of membrane membrane plasma membrane cell surface catenin complex Biological process hair cycle process positive regulation of keratinocyte proliferation negative regulation of timing of catagen response to stimulus keratinization wound healing regulation of hair cycle by canonical Wnt signaling pathway negative regulation of transforming growth factor beta2 production positive regulation of tyrosinase activity retina homeostasis positive regulation of gene expression cell adhesion positive regulation of insulin-like growth factor receptor signaling pathway canonical Wnt signaling pathway positive regulation of melanin biosynthetic process positive regulation of melanosome transport adherens junction organization visual perception homophilic cell adhesion via plasma membrane adhesion molecules cell-cell adhesion positive regulation of canonical Wnt signaling pathway cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1001 12560 Ensembl ENSG00000062038 ENSMUSG00000061048 UniProt P22223 P10287 RefSeq (mRNA) NM_001793 NM_001317195 NM_001317196 NM_001037809 NM_007665 RefSeq (protein) NP_001304124 NP_001304125 NP_001784 NP_001032898 NP_031691 Location (UCSC) Chr 16: 68.64 – 68.73 Mb Chr 8: 107.24 – 107.28 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas.

Clinical significance

Mutations in this gene have been associated with congenital hypotrichosis with juvenile macular dystrophy.^[6]

Interactions

CDH3 (gene) has been shown to interact with:

• Beta-catenin,^[7][8]
• CDH1,^[7]
• Catenin (cadherin-associated protein), alpha 1,^[7][8]
• Nephrin^[9] and
• Plakoglobin.^[7]

History

Cadherin-3 was first described in 1986 by Masatoshi Takeichi's laboratory as a new cadherin molecule most abundant in the developing mouse placenta – hence "P-cadherin".^[10][11]

See also

• EEM syndrome