CDH3 (gene)

Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.^[5][6]

CDH3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OY9
Identifiers
Aliases	CDH3, CDHP, HJMD, PCAD, cadherin 3
External IDs	OMIM: 114021; MGI: 88356; HomoloGene: 20425; GeneCards: CDH3; OMA:CDH3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 68,636,189 bp[1] End 68,727,468 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.16 cM Start 107,237,523 bp[2] End 107,283,929 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte lactiferous duct gingival epithelium olfactory zone of nasal mucosa left ovary retinal pigment epithelium nasal epithelium periodontal fiber right ovary hair follicle Top expressed in decidua gastrula choroid plexus of fourth ventricle genital tubercle tail of embryo lip otic vesicle saccule secondary oocyte molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding molecular function cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component cytoplasm integral component of membrane membrane plasma membrane cell surface catenin complex Biological process hair cycle process positive regulation of keratinocyte proliferation negative regulation of timing of catagen response to stimulus keratinization wound healing regulation of hair cycle by canonical Wnt signaling pathway negative regulation of transforming growth factor beta2 production positive regulation of tyrosinase activity retina homeostasis positive regulation of gene expression cell adhesion positive regulation of insulin-like growth factor receptor signaling pathway canonical Wnt signaling pathway positive regulation of melanin biosynthetic process positive regulation of melanosome transport adherens junction organization visual perception homophilic cell adhesion via plasma membrane adhesion molecules cell-cell adhesion positive regulation of canonical Wnt signaling pathway cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1001 12560 Ensembl ENSG00000062038 ENSMUSG00000061048 UniProt P22223 P10287 RefSeq (mRNA) NM_001793 NM_001317195 NM_001317196 NM_001037809 NM_007665 RefSeq (protein) NP_001304124 NP_001304125 NP_001784 NP_001032898 NP_031691 Location (UCSC) Chr 16: 68.64 – 68.73 Mb Chr 8: 107.24 – 107.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas.

Clinical significance

Mutations in this gene have been associated with congenital hypotrichosis with juvenile macular dystrophy.^[6]

Interactions

CDH3 (gene) has been shown to interact with:

• Beta-catenin,^[7][8]
• CDH1,^[7]
• Catenin (cadherin-associated protein), alpha 1,^[7][8]
• Nephrin^[9] and
• Plakoglobin.^[7]

History

Cadherin-3 was first described in 1986 by Masatoshi Takeichi's laboratory as a new cadherin molecule most abundant in the developing mouse placenta – hence "P-cadherin".^[10][11]

See also

• EEM syndrome

References

1. GRCh38: Ensembl release 89: ENSG00000062038 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061048 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
6. "Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)".
7. Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (Aug 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". Journal of Cell Science. 113 (16): 2829–36. doi:10.1242/jcs.113.16.2829. PMID 10910767.
8. Schmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation. 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. PMID 10381631.
9. Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (Sep 2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". The American Journal of Pathology. 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC 1618613. PMID 15331416.
10. Vieira AF, Paredes J (October 2015). "P-cadherin and the journey to cancer metastasis". Mol Cancer. 14: 178. doi:10.1186/s12943-015-0448-4. PMC 4595126. PMID 26438065.
11. Nose A, Takeichi M (December 1986). "A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos". J Cell Biol. 103 (6 Pt 2): 2649–58. doi:10.1083/jcb.103.6.2649. PMC 2114609. PMID 3539943.

Further reading

• Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (Oct 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 9156–60. Bibcode:1991PNAS...88.9156H. doi:10.1073/pnas.88.20.9156. PMC 52671. PMID 1924379.
• Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O (Apr 1989). "Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas". Cancer Research. 49 (8): 2128–33. PMID 2702654.
• Shimoyama Y, Yoshida T, Terada M, Shimosato Y, Abe O, Hirohashi S (Oct 1989). "Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues". The Journal of Cell Biology. 109 (4 Pt 1): 1787–94. doi:10.1083/jcb.109.4.1787. PMC 2115800. PMID 2793940.
• Palacios J, Benito N, Pizarro A, Suárez A, Espada J, Cano A, Gamallo C (Mar 1995). "Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features". The American Journal of Pathology. 146 (3): 605–12. PMC 1869170. PMID 7534041.
• van der Linden PJ, de Goeij AF, Dunselman GA, Erkens HW, Evers JL (Jun 1995). "Expression of cadherins and integrins in human endometrium throughout the menstrual cycle". Fertility and Sterility. 63 (6): 1210–6. doi:10.1016/s0015-0282(16)57599-2. PMID 7538474.
• Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA (Apr 1994). "E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro". Journal of Cell Science. 107 (4): 983–92. doi:10.1242/jcs.107.4.983. PMID 8056851.
• Tassin MT, Beziau A, Gubler MC, Boyer B (Mar 1994). "Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes". The International Journal of Developmental Biology. 38 (1): 45–54. PMID 8074995.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Navarro P, Lozano E, Cano A (Aug 1993). "Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin". Journal of Cell Science. 105 (4): 923–34. doi:10.1242/jcs.105.4.923. hdl:10261/78716. PMID 8227214.
• Reynolds AB, Daniel JM, Mo YY, Wu J, Zhang Z (Jun 1996). "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts". Experimental Cell Research. 225 (2): 328–37. doi:10.1006/excr.1996.0183. PMID 8660921.
• Soler AP, Harner GD, Knudsen KA, McBrearty FX, Grujic E, Salazar H, Han AC, Keshgegian AA (Aug 1997). "Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology". The American Journal of Pathology. 151 (2): 471–8. PMC 1858007. PMID 9250159.
• Wakita H, Furukawa F, Baba S, Takigawa M (Nov 1997). "Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation". International Journal of Cancer. 73 (3): 432–9. doi:10.1002/(SICI)1097-0215(19971104)73:3<432::AID-IJC19>3.0.CO;2-E. PMID 9359492. S2CID 6333793.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (May 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
• Jarrard DF, Paul R, van Bokhoven A, Nguyen SH, Bova GS, Wheelock MJ, Johnson KR, Schalken J, Bussemakers M, Isaacs WB (Nov 1997). "P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer". Clinical Cancer Research. 3 (11): 2121–8. PMID 9815605.
• Schmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation. 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. PMID 10381631.
• Rufas O, Fisch B, Ziv S, Shalgi R (Feb 2000). "Expression of cadherin adhesion molecules on human gametes". Molecular Human Reproduction. 6 (2): 163–9. doi:10.1093/molehr/6.2.163. PMID 10655458.
• Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (Aug 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". Journal of Cell Science. 113 (16): 2829–36. doi:10.1242/jcs.113.16.2829. PMID 10910767.
• Han AC, Edelson MI, Peralta Soler A, Knudsen KA, Lifschitz-Mercer B, Czernobilsky B, Rosenblum NG, Salazar H (Nov 2000). "Cadherin expression in glandular tumors of the cervix". Cancer. 89 (10): 2053–8. doi:10.1002/1097-0142(20001115)89:10<2053::AID-CNCR4>3.0.CO;2-C. PMID 11066045. S2CID 39826325.
• Bauer K, Gosau M, Reinders J, Oefner P, Reichert TE, Bauer R (Nov 2013). "Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines". Carcinogenesis. 34 (11): 2622–8. doi:10.1093/carcin/bgt211. PMID 23740836.

External links

• CDH3 human gene location in the UCSC Genome Browser.
• CDH3 human gene details in the UCSC Genome Browser.