CDGSH iron sulfur domain

The CDGSH iron sulfur domain are a group of iron-sulfur (2Fe-2S) clusters and a unique 39 amino acid CDGSH domain [C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H].

CDGSH iron sulfur domain
Crystallographic structure (PDB: 2QH7​) of the CDGSH-type domain 1 dimer (green and cyan cartoon) complexed with iron (brown) and sulfur (yellow) Fe-S clusters.
Identifiers
Symbol	CDGSH
Pfam	PF10660
InterPro	IPR019610
Membranome	212
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

CDGSH iron sulfur domain 1
Identifiers
Symbol	CISD1
Alt. symbols	C10orf70, ZCD1
NCBI gene	55847
HGNC	30880
PDB	2QH7
RefSeq	NM_018464
UniProt	Q9NZ45
Other data
Locus	Chr. 10 q21.3
Search for Structures Swiss-model Domains InterPro

CDGSH iron sulfur domain 2
Identifiers
Symbol	CISD2
Alt. symbols	ZCD2
NCBI gene	493856
HGNC	24212
RefSeq	NM_001008388
UniProt	Q7Z3D5
Other data
Locus	Chr. 4 q24
Search for Structures Swiss-model Domains InterPro

CDGSH iron sulfur domain 3
Identifiers
Symbol	CISD3
NCBI gene	284106
HGNC	27578
Other data
Locus	Chr. 17 q12

The CDGSH iron sulfur domain 1 protein (also referred to as mitoNEET) is an integral membrane protein located in the outer mitochondrial membrane and whose function may be to transport iron into the mitochondria.^[1] Iron in turn is essential for the function of several mitochondrial enzymes.

The antidiabetic drug pioglitazone, in addition to binding to the nuclear receptor PPAR, also has been shown to bind mitoNEET with approximately equal affinity.^[2]