CD98

CD98 is a glycoprotein^[1][2] that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids.^[3] LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.^[3]

solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport)
Identifiers
Symbol	SLC3A2
Alt. symbols	MDU1, 4T2HC, 4F2, NACAE, CD98
NCBI gene	6520
HGNC	11026
OMIM	158070
RefSeq	NM_001013251
UniProt	P08195
Other data
Locus	Chr. 11 q12-q22
Search for Structures Swiss-model Domains InterPro

solute carrier family 7 member 5 (cationic amino acid transporter, y+ system)
Identifiers
Symbol	SLC7A5
Alt. symbols	LAT1, E16, D16S469E, MPE16, CD98
NCBI gene	8140
HGNC	11063
OMIM	600182
RefSeq	NM_003486
UniProt	Q01650
Other data
Locus	Chr. 16 q24.3
Search for Structures Swiss-model Domains InterPro

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

• 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene ^[4]
• CD98 light subunit protein encoded by the SLC7A5 gene^[5]

See also

• Cluster of differentiation
• Transmembrane protein
• Transport protein
• Solute carrier family

References

1. Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. doi:10.1038/labinvest.3700289. PMID 15880135. S2CID 19733993.
2. Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics. 5 (14): 3637–45. doi:10.1002/pmic.200401224. PMID 16097038. S2CID 31954787.
3. Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999). "Selective expression of the large neutral amino acid transporter at the blood–brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 12079–84. Bibcode:1999PNAS...9612079B. doi:10.1073/pnas.96.21.12079. PMC 18415. PMID 10518579.
4. Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflügers Arch. 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309. S2CID 25808108.
5. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters" (PDF). Pflügers Arch. 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310. S2CID 11670040.

External links

• CD98+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Large+Neutral+Amino+Acid-Transporter+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Amino+Acid+Transport+System+L at the U.S. National Library of Medicine Medical Subject Headings (MeSH)