CD3D

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.^[5]

CD3D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XIW
Identifiers
Aliases	CD3D, CD3-DELTA, IMD19, T3D, CD3d molecule, CD3 delta subunit of T-cell receptor complex, CD3DELTA
External IDs	OMIM: 186790; MGI: 88331; HomoloGene: 585; GeneCards: CD3D; OMA:CD3D - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,339,075 bp[1] End 118,342,705 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 44,893,084 bp[2] End 44,898,637 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus granulocyte lymph node appendix blood spleen epithelium of nasopharynx testicle mucosa of ileum bone marrow Top expressed in thymus mesenteric lymph nodes blood spleen granulocyte subcutaneous adipose tissue pharynx right lung lobe spermatid superior surface of tongue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein heterodimerization activity transmembrane signaling receptor activity protein homodimerization activity Cellular component membrane cytoplasm alpha-beta T cell receptor complex integral component of membrane T cell receptor complex clathrin-coated vesicle membrane plasma membrane external side of plasma membrane Biological process positive regulation of transcription by RNA polymerase II regulation of immune response T cell receptor signaling pathway T cell differentiation positive thymic T cell selection cell surface receptor signaling pathway membrane organization protein homooligomerization adaptive immune response immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 915 12500 Ensembl ENSG00000167286 ENSMUSG00000032094 UniProt P04234 P04235 RefSeq (mRNA) NM_001040651 NM_000732 NM_013487 RefSeq (protein) NP_000723 NP_001035741 NP_038515 Location (UCSC) Chr 11: 118.34 – 118.34 Mb Chr 9: 44.89 – 44.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CD3D has been shown to interact with CD8A.^[6]

See also

• CD3 (immunology)
• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000167286 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032094 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)".
6. Doucey MA, Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5). United States: 3257–64. doi:10.1074/jbc.M208119200. ISSN 0021-9258. PMID 12215456.

Further reading

• Balk SP, Polischuk JE, Probert C, et al. (1996). "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain". Int. Immunol. 7 (8): 1237–41. doi:10.1093/intimm/7.8.1237. PMID 7495730.
• Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference". J. Cell. Physiol. 209 (3): 695–700. doi:10.1002/jcp.20817. PMID 17001685. S2CID 37846031.
• Phillips JH, Hori T, Nagler A, et al. (1992). "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins". J. Exp. Med. 175 (4): 1055–66. doi:10.1084/jem.175.4.1055. PMC 2119193. PMID 1372642.
• Luzzati AL, Giacomini E, Giordani L, et al. (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol. Lett. 33 (3): 307–14. doi:10.1016/0165-2478(92)90078-3. PMID 1385321.
• Alarcón B, Ley SC, Sánchez-Madrid F, et al. (1991). "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes". EMBO J. 10 (4): 903–12. doi:10.1002/j.1460-2075.1991.tb08023.x. PMC 452733. PMID 1826255.
• Hori T, de Waal Malefyt R, Duncan BW, et al. (1991). "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3". Int. Immunol. 3 (4): 353–7. doi:10.1093/intimm/3.4.353. PMID 1831653.
• Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1): 1–13. doi:10.1016/0008-8749(91)90051-C. PMID 1832084.
• Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
• Luzzati AL, Pugliese O, Giacomini E, et al. (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV". Folia Biol. (Praha). 36 (1): 71–7. PMID 2111780.
• Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083. S2CID 2180901.
• Alexander D, Goris J, Marais R, et al. (1989). "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1): 55–65. doi:10.1111/j.1432-1033.1989.tb14693.x. PMID 2540970.
• Tunnacliffe A, Buluwela L, Rabbitts TH (1988). "Physical linkage of three CD3 genes on human chromosome 11". EMBO J. 6 (10): 2953–7. doi:10.1002/j.1460-2075.1987.tb02600.x. PMC 553731. PMID 2826124.
• van den Elsen P, Shepley BA, Cho M, Terhorst C (1985). "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein". Nature. 314 (6011): 542–4. Bibcode:1985Natur.314..542V. doi:10.1038/314542a0. PMID 2859526. S2CID 4321989.
• van den Elsen P, Georgopoulos K, Shepley BA, et al. (1986). "Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex". Proc. Natl. Acad. Sci. U.S.A. 83 (9): 2944–8. Bibcode:1986PNAS...83.2944V. doi:10.1073/pnas.83.9.2944. PMC 323423. PMID 2939461.
• Gold DP, Clevers H, Alarcon B, et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. Bibcode:1987PNAS...84.7649G. doi:10.1073/pnas.84.21.7649. PMC 299357. PMID 3478717.
• Tunnacliffe A, Sims JE, Rabbitts TH (1986). "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells". EMBO J. 5 (6): 1245–52. doi:10.1002/j.1460-2075.1986.tb04353.x. PMC 1166934. PMID 3488209.
• van den Elsen P, Shepley BA, Borst J, et al. (1985). "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature. 312 (5993): 413–8. Bibcode:1984Natur.312..413V. doi:10.1038/312413a0. PMID 6095101. S2CID 4347265.
• Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120". AIDS Res. Hum. Retroviruses. 9 (10): 945–55. doi:10.1089/aid.1993.9.945. PMID 7506554.
• Luzzati AL, Giacomini E, Giordani L, et al. (1994). "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex". Cell. Immunol. 156 (2): 286–95. doi:10.1006/cimm.1994.1175. PMID 7517794.

External links

• Human CD3D genome location and CD3D gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P04234 (T-cell surface glycoprotein CD3 delta chain) at the PDBe-KB.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.