CACNG1

Voltage-dependent calcium channel gamma-1 subunit is a protein that in humans is encoded by the CACNG1 gene.^[5][6]

CACNG1
Identifiers
Aliases	CACNG1, CACNLG, calcium voltage-gated channel auxiliary subunit gamma 1
External IDs	OMIM: 114209; MGI: 1206582; HomoloGene: 582; GeneCards: CACNG1; OMA:CACNG1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q24.2 Start 67,044,554 bp[1] End 67,056,797 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 107,594,044 bp[2] End 107,607,348 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh triceps brachii muscle quadriceps femoris muscle vastus lateralis muscle skeletal muscle tissue Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii glutes thoracic diaphragm Top expressed in muscle of thigh masseter muscle temporal muscle extensor digitorum longus muscle ankle medial head of gastrocnemius muscle plantaris muscle quadriceps femoris muscle tibialis anterior muscle triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated calcium channel activity protein binding voltage-gated ion channel activity calcium channel activity calcium channel regulator activity Cellular component voltage-gated calcium channel complex integral component of membrane plasma membrane membrane integral component of plasma membrane T-tubule sarcolemma L-type voltage-gated calcium channel complex Biological process regulation of ion transmembrane transport muscle contraction ion transport calcium ion transmembrane transport sarcoplasmic reticulum calcium ion transport calcium ion transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 786 12299 Ensembl ENSG00000108878 ENSMUSG00000020722 UniProt Q06432 O70578 RefSeq (mRNA) NM_000727 NM_007582 RefSeq (protein) NP_000718 NP_031608 Location (UCSC) Chr 17: 67.04 – 67.06 Mb Chr 11: 107.59 – 107.61 Mb PubMed search [3] [4]
Wikidata
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L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.^[6]

See also

• Voltage-dependent calcium channel