C1QTNF3

Complement C1q tumor necrosis factor-related protein 3 is a protein that in humans is encoded by the C1QTNF3 gene.^[5][6]

C1QTNF3
Identifiers
Aliases	C1QTNF3, C1ATNF3, CORCS, CORS, CORS-26, CORS26, CTRP3, C1q and tumor necrosis factor related protein 3, C1q and TNF related 3
External IDs	OMIM: 612045; MGI: 1932136; HomoloGene: 12788; GeneCards: C1QTNF3; OMA:C1QTNF3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.2 Start 34,017,858 bp[1] End 34,043,213 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 Start 10,952,418 bp[2] End 10,980,236 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland Achilles tendon cartilage tissue vena cava cardia right testis left testis skin of hip synovial joint epithelium of colon Top expressed in right kidney dermis human fetus muscle of thorax proximal tubule body of femur human kidney cervix condyle umbilical cord More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component extracellular region collagen extracellular exosome membrane extracellular space Biological process cellular triglyceride homeostasis negative regulation of monocyte chemotactic protein-1 production negative regulation of gluconeogenesis protein trimerization fat cell differentiation negative regulation of inflammatory response negative regulation of gene expression positive regulation of adiponectin secretion negative regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114899 81799 Ensembl ENSG00000082196 ENSMUSG00000058914 UniProt Q9BXJ4 Q9ES30 RefSeq (mRNA) NM_181435 NM_030945 NM_001204134 NM_030888 RefSeq (protein) NP_112207 NP_852100 NP_001191063 NP_112150 Location (UCSC) Chr 5: 34.02 – 34.04 Mb Chr 15: 10.95 – 10.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000082196 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058914 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wölfing B, Buechler C, Weigert J, Neumeier M, Aslanidis C, Schöelmerich J, Schäffler A (Jul 2008). "Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines". Obesity. 16 (7): 1481–1486. doi:10.1038/oby.2008.206. PMID 18421280. S2CID 40979522.
6. "Entrez Gene: C1QTNF3 C1q and tumor necrosis factor related protein 3".

External links

• Human C1QTNF3 genome location and C1QTNF3 gene details page in the UCSC Genome Browser.

Further reading

• Akiyama H, Furukawa S, Wakisaka S, Maeda T (Oct 2007). "CTRP3/cartducin promotes proliferation and migration of endothelial cells". Molecular and Cellular Biochemistry. 304 (1–2): 243–248. doi:10.1007/s11010-007-9506-6. PMID 17534697. S2CID 25647563.
• Wurm S, Neumeier M, Weigert J, Schäffler A, Buechler C (2007). "Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults". Cardiovascular Diabetology. 6: 7. doi:10.1186/1475-2840-6-7. PMC 1804262. PMID 17311679.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Schäffler A, Ehling A, Neumann E, Herfarth H, Paul G, Tarner I, Gay S, Schölmerich J, Müller-Ladner U (Nov 2003). "Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1630 (2–3): 123–9. doi:10.1016/j.bbaexp.2003.08.013. PMID 14654242.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Maeda T, Abe M, Kurisu K, Jikko A, Furukawa S (Feb 2001). "Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development". The Journal of Biological Chemistry. 276 (5): 3628–3634. doi:10.1074/jbc.M007898200. PMID 11071891.