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Calcium channel blocker medication From Wikipedia, the free encyclopedia
Bepridil (trade name Vascor) is an diamine calcium channel blocker once used to treat angina pectoris. It is no longer sold in the United States.
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Clinical data | |
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Trade names | Vascor |
AHFS/Drugs.com | Monograph |
MedlinePlus | a699051 |
Routes of administration | Oral |
ATC code | |
Pharmacokinetic data | |
Bioavailability | Well absorbed |
Protein binding | 99% |
Metabolism | Hepatic, CYP3A4-mediated |
Elimination half-life | 42 hours |
Excretion | Renal |
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Chemical and physical data | |
Formula | C24H34N2O |
Molar mass | 366.549 g·mol−1 |
3D model (JSmol) | |
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It is nonselective.[1]
It has been discussed as a possible option in the treatment of atrial fibrillation.[2]
It has been implicated in causing ventricular arrhythmia (torsades de pointes).
In June 2015 a research paper [3] was published finding bepridil to result in a 100% survival rate for mice exposed to ebola during an experiment searching for potential pharmaceutical ebola treatments; indicating its potential use in future ebola research and therapy.[4]
A research paper [5] showed that Bepridil inhibited cytopathogenic effects induced by SARS-CoV-2 in Vero E6 cells and in A549 cells in an in vitro assay.
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