Benidipine

Benidipine is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension). It is a triple L-, T-, and N-type calcium channel blocker. It is reno- and cardioprotective.

Benidipine

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth
ATC code	C08CA15 (WHO)
Identifiers
IUPAC name O5-methyl O3-[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number	105979-17-7 Y
PubChem CID	656668
ChemSpider	571013 N
UNII	4G9T91JS7E
ChEMBL	ChEMBL2218858 N
Chemical and physical data
Formula	C28H31N3O6
Molar mass	505.571 g·mol−1
3D model (JSmol)	Interactive image
SMILES [O-][N+](=O)c1cccc(c1)[C@@H]4C(/C(=O)OC)=C(\N\C(=C4\C(=O)O[C@@H]3CCCN(Cc2ccccc2)C3)C)C
InChI InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1 N Key:QZVNQOLPLYWLHQ-ZEQKJWHPSA-N N
NY (what is this?)  (verify)

It was patented in 1981 and approved for medical use in 1991.^[1]

Dosing

Benidipine is dosed as 2–8 mg once daily.^[2]

Mechanism

Benidipine is a calcium channel blocker.

Benidipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid.^[3]

Names

Other names include Benidipinum or benidipine hydrochloride.

Benidipine is sold as Coniel by Kyowa Hakko Kogyo.

Benidipine is initially licensed for use in Japan and selected Southeast Asian countries and later in Turkey, where it is sold as 4 mg tablets.