BOC (gene)

Brother of CDO is a protein that in humans is encoded by the BOC gene.^[5][6]

BOC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N1G, 3N1M, 3N1P
Identifiers
Aliases	BOC, CDON2, BOC cell adhesion associated, oncogene regulated, Boi
External IDs	OMIM: 608708; MGI: 2151153; HomoloGene: 32819; GeneCards: BOC; OMA:BOC - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.2 Start 113,211,003 bp[1] End 113,287,459 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B4 Start 44,305,412 bp[2] End 44,379,260 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii ventricular zone left uterine tube skin of arm gastric mucosa parotid gland skin of thigh right uterine tube body of uterus tibia Top expressed in ventricular zone skin of external ear efferent ductule internal carotid artery vas deferens lip trachea ascending aorta conjunctival fornix aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane axonal growth cone integral component of plasma membrane membrane nucleoplasm Biological process smoothened signaling pathway cell adhesion positive regulation of myoblast differentiation positive regulation of muscle cell differentiation axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91653 117606 Ensembl ENSG00000144857 ENSMUSG00000022687 UniProt Q9BWV1 Q6AZB0 RefSeq (mRNA) NM_001301861 NM_001301867 NM_033254 NM_001378073 NM_001378074 NM_001378075 NM_001387919 NM_001387920 NM_001387921 NM_001387922 NM_001387923 NM_001387924 NM_001387925 NM_001387926 NM_001387927 NM_001387928 NM_001387929 NM_001387930 NM_001387932 NM_172506 RefSeq (protein) NP_001288790 NP_001288796 NP_150279 NP_001365002 NP_001365003 NP_001365004 NP_766094 Location (UCSC) Chr 3: 113.21 – 113.29 Mb Chr 16: 44.31 – 44.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CDON (MIM 608707) and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM]^[6]

Interactions

BOC (gene) has been shown to interact with CDON.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000144857 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022687 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kang JS, Mulieri PJ, Hu Y, Taliana L, Krauss RS (Jan 2002). "BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation". EMBO J. 21 (1–2): 114–24. doi:10.1093/emboj/21.1.114. PMC 125805. PMID 11782431.
6. "Entrez Gene: BOC Boc homolog (mouse)".

External links

• Human BOC genome location and BOC gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kang JS, Feinleib JL, Knox S, et al. (2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3989–94. Bibcode:2003PNAS..100.3989K. doi:10.1073/pnas.0736565100. PMC 153035. PMID 12634428.
• Wegorzewska M, Krauss RS, Kang JS (2003). "Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD". Mol. Carcinog. 37 (1): 1–4. doi:10.1002/mc.10121. PMID 12720294. S2CID 46652847.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kang JS, Yi MJ, Zhang W, et al. (2004). "Netrins and neogenin promote myotube formation". J. Cell Biol. 167 (3): 493–504. doi:10.1083/jcb.200405039. PMC 2172498. PMID 15520228.
• Tenzen T, Allen BL, Cole F, et al. (2006). "The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice". Dev. Cell. 10 (5): 647–56. doi:10.1016/j.devcel.2006.04.004. PMID 16647304.