BIRC6

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.^[5][6]

BIRC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CEG
Identifiers
Aliases	BIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6
External IDs	OMIM: 605638; MGI: 1276108; HomoloGene: 7248; GeneCards: BIRC6; OMA:BIRC6 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.3 Start 32,357,023 bp[1] End 32,618,878 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E2 Start 74,835,290 bp[2] End 75,010,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell Achilles tendon pancreatic ductal cell mucosa of ileum tibialis anterior muscle bone marrow cells epithelium of colon corpus callosum skin of arm mucosa of sigmoid colon Top expressed in tail of embryo internal carotid artery external carotid artery genital tubercle thymus seminal vesicula ventricular zone cumulus cell submandibular gland ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity cysteine-type endopeptidase inhibitor activity ubiquitin-protein transferase activity protein binding ubiquitin conjugating enzyme activity transferase activity Cellular component cytoplasm endosome spindle pole membrane microtubule organizing center trans-Golgi network cytoskeleton Golgi apparatus intracellular membrane-bounded organelle midbody Flemming body nucleus Biological process negative regulation of peptidase activity spongiotrophoblast layer development regulation of cytokinesis placenta development labyrinthine layer development negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process cell division protein phosphorylation regulation of cell population proliferation protein ubiquitination positive regulation of cell population proliferation cell cycle apoptotic process negative regulation of endopeptidase activity ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57448 12211 Ensembl ENSG00000115760 ENSMUSG00000024073 UniProt Q9NR09 O88738 RefSeq (mRNA) NM_016252 NM_001378125 NM_007566 RefSeq (protein) NP_057336 NP_001365054 NP_031592 NP_001389698 Location (UCSC) Chr 2: 32.36 – 32.62 Mb Chr 17: 74.84 – 75.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.^[6]

Interactions

BIRC6 has been shown to interact with KIF23.^[7]

Diseases

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers^[8] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology^[9]).

References

1. GRCh38: Ensembl release 89: ENSG00000115760 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024073 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.
6. "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)".
7. Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell. 132 (5): 832–45. doi:10.1016/j.cell.2008.01.012. PMID 18329369. S2CID 12192141.
8. "BIRC6 (Baculoviral IAP repeat-containing 6)". atlasgeneticsoncology.org.
9. "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.

External links

• Human BIRC6 genome location and BIRC6 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Baculoviral IAP repeat-containing protein 6

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Qiu XB, Markant SL, Yuan J, Goldberg AL (2005). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMC 380992. PMID 14765125.
• Bartke T, Pohl C, Pyrowolakis G, Jentsch S (2005). "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase". Mol. Cell. 14 (6): 801–11. doi:10.1016/j.molcel.2004.05.018. PMID 15200957.
• Hao Y, Sekine K, Kawabata A, Nakamura H, Ishioka T, Ohata H, Katayama R, Hashimoto C, Zhang X, Noda T, Tsuruo T, Naito M (2004). "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function". Nat. Cell Biol. 6 (9): 849–60. doi:10.1038/ncb1159. PMID 15300255. S2CID 22850781.
• Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
• Qiu XB, Goldberg AL (2005). "The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9". J. Biol. Chem. 280 (1): 174–82. doi:10.1074/jbc.M411430200. PMID 15507451.