BIRC6

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.^[5][6]

BIRC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CEG
Identifiers
Aliases	BIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6
External IDs	OMIM: 605638; MGI: 1276108; HomoloGene: 7248; GeneCards: BIRC6; OMA:BIRC6 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.3 Start 32,357,023 bp[1] End 32,618,878 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E2 Start 74,835,290 bp[2] End 75,010,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell Achilles tendon pancreatic ductal cell mucosa of ileum tibialis anterior muscle bone marrow cells epithelium of colon corpus callosum skin of arm mucosa of sigmoid colon Top expressed in tail of embryo internal carotid artery external carotid artery genital tubercle thymus seminal vesicula ventricular zone cumulus cell submandibular gland ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity cysteine-type endopeptidase inhibitor activity ubiquitin-protein transferase activity protein binding ubiquitin conjugating enzyme activity transferase activity Cellular component cytoplasm endosome spindle pole membrane microtubule organizing center trans-Golgi network cytoskeleton Golgi apparatus intracellular membrane-bounded organelle midbody Flemming body nucleus Biological process negative regulation of peptidase activity spongiotrophoblast layer development regulation of cytokinesis placenta development labyrinthine layer development negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process cell division protein phosphorylation regulation of cell population proliferation protein ubiquitination positive regulation of cell population proliferation cell cycle apoptotic process negative regulation of endopeptidase activity ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57448 12211 Ensembl ENSG00000115760 ENSMUSG00000024073 UniProt Q9NR09 O88738 RefSeq (mRNA) NM_016252 NM_001378125 NM_007566 RefSeq (protein) NP_057336 NP_001365054 NP_031592 NP_001389698 Location (UCSC) Chr 2: 32.36 – 32.62 Mb Chr 17: 74.84 – 75.01 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.^[6]

Interactions

BIRC6 has been shown to interact with KIF23.^[7]

Diseases

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers^[8] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology^[9]).