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Chemical compound From Wikipedia, the free encyclopedia
Avutometinib (INN; codenamed RO-5126766, CH-5126766, CKI-27, R-7304, RG-7304, and VS-6766 at various stages of its development) is an inhibitor of Ras-Raf-MEK-ERK signaling being developed as a potential treatment for cancer.
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Other names | RO-5126766; CH-5126766; CKI-27; R-7304; RG-7304 |
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Elimination half-life | 60 h (45.8–93.7 h) |
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Formula | C21H18FN5O5S |
Molar mass | 471.46 g·mol−1 |
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It was discovered by Chugai Pharmaceutical Co. (a subsidiary of Roche) through derivatization of a hit compound identified by high-throughput screening.[1] It was licensed by Verastem Oncology in 2020 for clinical trials.[2][3]
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