Arylsulfatase

Arylsulfatase (EC 3.1.6.1, sulfatase, nitrocatechol sulfatase, phenolsulfatase, phenylsulfatase, p-nitrophenyl sulfatase, arylsulfohydrolase, 4-methylumbelliferyl sulfatase, estrogen sulfatase) is a type of sulfatase enzyme with systematic name aryl-sulfate sulfohydrolase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

an aryl sulfate + H₂O ${\displaystyle \rightleftharpoons }$ a phenol + sulfate

Arylsulfatase
Arylsulfatase monomer, Pseudomonas aeruginosa
Identifiers
EC no.	3.1.6.1
CAS no.	9016-17-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

It catalyses an analogous reaction for sulfonated hexoses. Types include:

• Arylsulfatase A (also known as "cerebroside-sulfatase")
• Arylsulfatase B (also known as "N-acetylgalactosamine-4-sulfatase")
• Steroid sulfatase (formerly known as "arylsulfatase C")
• ARSC2
• ARSD
• ARSF
• ARSG
• ARSH
• ARSI
• ARSJ
• ARSK
• ARSL (formerly known as "arylsulfatase E", "ARSE")

See also

• Aryl

References

1. Dodgson KS, Spencer B, Williams K (October 1956). "Studies on sulphatases. 13. The hydrolysis of substituted phenyl sulphates by the arylsulphatase of Alcaligenes metalcaligenes". The Biochemical Journal. 64 (2): 216–21. PMC 1199721. PMID 13363831.
2. Roy AB (1960). "The synthesis and hydrolysis of sulfate esters". Advances in Enzymology and Related Subjects of Biochemistry. 22: 205–35. PMID 13744184.
3. Roy AB (April 1976). "Sulphatases, lysosomes and disease". The Australian Journal of Experimental Biology and Medical Science. 54 (2): 111–35. doi:10.1038/icb.1976.13. PMID 13772.
4. Webb EC, Morrow PF (September 1959). "The activation of an arysulphatase from ox liver by chloride and other anions". The Biochemical Journal. 73 (1): 7–15. PMC 1197004. PMID 13843260.