Aryl hydrocarbon receptor nuclear translocator

The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL–ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

ARNT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PKY, 1X0O, 2A24, 2B02, 2HV1, 2K7S, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4EQ1, 4GHI, 4GS9, 4H6J, 4LPZ, 4XT2
Identifiers
Aliases	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator
External IDs	OMIM: 126110; MGI: 88071; HomoloGene: 1261; GeneCards: ARNT; OMA:ARNT - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 150,809,713 bp[1] End 150,876,708 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.1|3 40.74 cM Start 95,341,699 bp[2] End 95,404,551 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon Achilles tendon sural nerve canal of the cervix left ovary right ovary gastric mucosa stromal cell of endometrium ectocervix body of uterus Top expressed in ascending aorta aortic valve parotid gland muscle of thigh tongue cumulus cell molar atrium pineal gland external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein dimerization activity DNA-binding transcription factor activity transcription coactivator activity aryl hydrocarbon receptor binding transcription factor binding protein binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific protein homodimerization activity sequence-specific double-stranded DNA binding nuclear receptor activity Cellular component cytoplasm transcription regulator complex nucleoplasm RNA polymerase II transcription regulator complex nucleus nuclear body Biological process positive regulation of vascular endothelial growth factor receptor signaling pathway cell differentiation response to hypoxia regulation of transcription, DNA-templated positive regulation of endothelial cell proliferation regulation of transcription from RNA polymerase II promoter in response to oxidative stress positive regulation of erythrocyte differentiation embryonic placenta development mRNA transcription by RNA polymerase II positive regulation of protein sumoylation transcription, DNA-templated positive regulation of transcription, DNA-templated intracellular receptor signaling pathway regulation of transcription from RNA polymerase II promoter in response to hypoxia positive regulation of vascular endothelial growth factor production positive regulation of glycolytic process positive regulation of transcription by RNA polymerase II positive regulation of hormone biosynthetic process xenobiotic metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 405 11863 Ensembl ENSG00000143437 ENSMUSG00000015522 UniProt P27540 P53762 RefSeq (mRNA) NM_001197325 NM_001286035 NM_001286036 NM_001668 NM_178426 NM_178427 NM_001350224 NM_001350225 NM_001350226 NM_001037737 NM_009709 RefSeq (protein) NP_001184254 NP_001272964 NP_001272965 NP_001659 NP_848514 NP_001337153 NP_001337154 NP_001337155 NP_001032826 NP_033839 Location (UCSC) Chr 1: 150.81 – 150.88 Mb Chr 3: 95.34 – 95.4 Mb PubMed search [3] [4]
Wikidata
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The aryl hydrocarbon receptor (AhR) is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the aryl hydrocarbon receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only into^{[verification needed]} the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound AhR to xenobiotic responsive elements in the promoters of genes for these enzymes.

Interactions

Aryl hydrocarbon receptor nuclear translocator has been shown to interact with:

• AIP,^[5][6]
• AHR,^{[7][8][9][10]}
• EPAS1,^[11]
• HIF1A,^[11][12]
• NCOA2,^[13]
• SIM1,^[12][14] and
• SIM2.^{[12][14][15][16]}