Antisialagogue

Antisialagogues are drugs or substances that decrease the flow rate of saliva and their effect is opposite to that of sialagogues.^[1] Their origin may be both natural and synthetic.

Anticholinergics generally have antisialagogue effects, and most produce some level of sedation, both being advantageous in surgical procedures.^[2]

Classic antisialagogues^[1] include:

• atropine,
• opioids,
• alkalis,
• hyoscyamine,
• scopolamine,
• tobacco in excess,
• most cannabinoids,^[3]
• all nauseous or insipid substances.

References

1. Dock LL (1916). "Drugs Acting On The Salivary Glands". Text-Book Of Materia Medica For Nurses. G. P. Putnam's Sons. Retrieved 15 October 2010.
2. Hata TM, Moyers JR (2009). "Preoperative Patient Assessment and Management". In Cahalan MD, Barash PG, Cullen BF, Stoelting RK (eds.). Clinical Anesthesia. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 592. ISBN 978-0-7817-8763-5.
3. Prestifilippo, Juan Pablo; Fernández-Solari, Javier; de la Cal, Carolina; Iribarne, María; Suburo, Angela M.; Rettori, Valeria; McCann, Samuel M.; Elverdin, Juan Carlos (September 2006). "Inhibition of salivary secretion by activation of cannabinoid receptors". Experimental Biology and Medicine (Maywood, N.J.). pp. 1421–1429. doi:10.1177/153537020623100816. Retrieved 17 June 2023.