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Anna Marie Pyle is an American academic who is a Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Chemistry at Yale University. and an Investigator for Howard Hughes Medical Institute.[1] Pyle is the president of the RNA Society,[2] the vice-chair of the Science and Technology Steering Committee at Brookhaven National Laboratory, and previously she served as chair of the Macromolecular Structure and Function A Study Section[3] at the National Institutes of Health.
Anna Marie Pyle | |
|---|---|
| Alma mater | Princeton University, Columbia University |
| Scientific career | |
| Institutions | Yale University, University of Colorado |
Pyle grew up in Albuquerque, New Mexico, and it was there that she first became interested in science.[4] But it wasn't until after earning her bachelor's degree from Princeton University that she committed to a career in chemistry.[4] In 1990, she graduated from Columbia University with a Ph.D. in chemistry. Pyle went on to postdoc at the University of Colorado until in 1992 she established a research group at Columbia University Medical Center in the Department of Biochemistry and Molecular Biophysics. In 2002, she moved to Yale University.[1]
Pyle joined Yale University in 2002. She researches the architectural features of large RNA molecules and RNA remodeling enzymes using experimental biochemistry and crystallography. such as self-splicing introns and other noncoding RNAs. She has focused her research to understand how large RNAs assemble into specific, stable tertiary structures, and also how ATP-dependent enzymes in the cell recognize and remodel RNA. Specifically, she was successful in crystallizing and solving the structure of a group IIC intron from the bacterium Oceanobacillus iheyensis[5] and moves through the stages of splicing.[6] Pyle's research may be helpful in drug development as RNA's tertiary structure could provide insight into druggable biomolecules.[7][8]
- 2023 Elected member of the U.S. National Academy of Sciences[9]
- 2018 Appointed as Sterling Professor of Molecular, Cellular, and Developmental Biology[10]
- 2007 Elected American Association for the Advancement of Science (AAAS) Fellow[11]
- 2005 Appointed member of the American Academy of Arts and Sciences[12]
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