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Type of tumor which affects children and adolescents From Wikipedia, the free encyclopedia
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue cancer that affects children and young adults.
| Angiomatoid fibrous histiocytoma | |
|---|---|
| |
| Micrograph showing an angiomatoid fibrous histiocytoma. H&E stain. |
It is characterized by cystic blood-filled spaces and composed of histiocyte-like cells. A lymphocytic cuff is common. It often simulates a vascular lesion, and was initially described as doing this.[1]
AFH typically has a chromosomal translocation involving the ATF1 gene -- t(12;16) FUS/ATF1 or t(12;22) EWS/ATF1.[2]
![[icon]](#/media/File:Wiki_letter_w_cropped.svg){kind=small} | This section is empty. You can help by adding to it. (December 2017) |
| This section is empty. You can help by adding to it. (December 2017) |
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