Angiomatoid fibrous histiocytoma

Type of tumor which affects children and adolescents From Wikipedia, the free encyclopedia

Angiomatoid fibrous histiocytoma

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue cancer that affects children and young adults.

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Angiomatoid fibrous histiocytoma
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Micrograph showing an angiomatoid fibrous histiocytoma. H&E stain.
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Pathology

It is characterized by cystic blood-filled spaces and composed of histiocyte-like cells. A lymphocytic cuff is common. It often simulates a vascular lesion, and was initially described as doing this.[1]

AFH typically has a chromosomal translocation involving the ATF1 gene -- t(12;16) FUS/ATF1 or t(12;22) EWS/ATF1.[2]

Diagnosis

Treatment

See also

References

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