Alpha/beta hydrolase superfamily
Protein family From Wikipedia, the free encyclopedia
The alpha/beta hydrolase superfamily is a superfamily of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function that share a common fold.[1] The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 beta strands connected by 6 alpha helices.[1][2] The enzymes are believed to have diverged from a common ancestor, retaining little obvious sequence similarity, but preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best-conserved structural features of the fold.
A bacterial lipase, one of this family members | |||||||||
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | Abhydrolase_1 | ||||||||
| Pfam | PF00561 | ||||||||
| Pfam clan | CL0028 | ||||||||
| ECOD | 7579.1.1 | ||||||||
| InterPro | IPR029058 | ||||||||
| SCOP2 | 1ede / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 127 | ||||||||
| OPM protein | 1qge | ||||||||
| CDD | cl21494 | ||||||||
| Membranome | 300 | ||||||||
| |||||||||
The alpha/beta hydrolase fold includes proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases.[3]
Database
The ESTHER database provides a large collection of information about this superfamily of proteins.[4]
Subfamilies
Human proteins containing this domain
ABHD10; ABHD11; ABHD12; ABHD12B; ABHD13; ABHD2; ABHD3; ABHD4; ABHD5; ABHD6; ABHD7; ABHD8; ABHD9; BAT5; BPHL; C20orf135; EPHX1; EPHX2; FAM108B1; LIPA; LIPF; LIPJ; LIPK; LIPM; LIPN; LYPLAL1; MEST; MGLL; PPME1; SERHL; SERHL2; SPG21; CES1; CES2; C4orf29
See also
- Ecdysteroid-phosphate phosphatase - structure of a steroid phosphate phosphotase
- Serine hydrolase - an enzyme family that is composed largely of proteins with alpha-beta hydrolase folds
External links
References
Wikiwand - on
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