Acute panmyelosis with myelofibrosis
Medical condition From Wikipedia, the free encyclopedia
Acute panmyelosis with myelofibrosis (APMF) is a poorly defined disorder that arises as either a clonal disorder, or following toxic exposure to the bone marrow.[1]
| Acute panmyelosis with myelofibrosis | |
|---|---|
| Specialty | Hematology, oncology |
Signs and symptoms
Bone biopsy shows abnormal megakaryocytes, macrocytic erythropoiesis, and defects in neutrophil production and fibrosis of the marrow (myelofibrosis).
Clinically, patients present with reduction in the count of all blood cells (pancytopenia), very few blasts in the peripheral blood, and no or little spleen enlargement (splenomegaly).
Prognosis and treatment
Autologous stem cell transplantation has been used in treatment.[3]
Terminology
Controversy remains today whether this disorder is a subtype of acute myeloid leukemia or myelodysplastic syndromes; however, it is currently classified as a form of AML.[4][5]
See also
References
See also
External links
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