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Acetoacetanilide

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Acetoacetanilide

Acetoacetanilide is an organic compound with the formula CH3C(O)CH2C(O)NHC6H5. It is the acetoacetamide derivative of aniline. It is a white solid that is poorly soluble in water. This chemical and many related compounds (prepared from various aniline derivatives) are used in the production of organic pigments called arylide yellows, one example being Pigment Yellow 74.

Quick Facts Names, Identifiers ...
Acetoacetanilide
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Names
Preferred IUPAC name
3-Oxo-N-phenylbutanamide
Other names
Acetoacetylaminobenzene
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.002.725
EC Number
  • 202-996-4
UNII
  • InChI=1S/C10H11NO2/c1-8(12)7-10(13)11-9-5-3-2-4-6-9/h2-6H,7H2,1H3,(H,11,13)
    Key: DYRDKSSFIWVSNM-UHFFFAOYSA-N
  • InChI=1/C10H11NO2/c1-8(12)7-10(13)11-9-5-3-2-4-6-9/h2-6H,7H2,1H3,(H,11,13)
    Key: DYRDKSSFIWVSNM-UHFFFAOYAR
  • CC(=O)CC(=O)NC1=CC=CC=C1
Properties
C10H11NO2
Molar mass 177.203 g·mol−1
Appearance Colourless solid
Melting point 83 to 88 °C (181 to 190 °F; 356 to 361 K)
low
Hazards
GHS labelling:
GHS07: Exclamation markGHS08: Health hazard
Warning
H302, H312, H332, H373
P260, P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P314, P322, P330, P363, P501
NFPA 704 (fire diamond)
ThumbHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
2
1
0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Structure

Acetoacetanilide crystallizes as the keto-amide tautomer according to X-ray crystallography. The molecules are linked by intermolecular hydrogen bonds, which allows the benzoyl ketone to rotate out of the plane of the amide.[1] For the general case of substituted acetoanilides, substituents on the aryl ring affect the balance of intra- vs intermolecular hydrogen bonding.[2] The situation is illustrated by the 2' vs. 3' vs. 4' fluoro-substituted acetoacetanilides.[3]

Preparation and reactions

Acetoacetanilide is prepared by acetoacetylation of aniline using diketene.[4] Many analogues have been prepared.[5]

To make the dyes, acetoacetanilides are coupled to diazonium salts, "azo coupling".[6]

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Acetoacetylation with diketene followed by diazo coupling. The ketohydrazone tautomer is shown.

In the presence of sulfuric acid, acetoacetanilide dehydrates to give 4-methyl-2-quinolone.[7]

Related compounds

  • Acetoacetamide, CH3COCH2CONH2
  • C10H11NO2

References

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