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Antimicrobial drug From Wikipedia, the free encyclopedia
Acedapsone (INN) is an antimicrobial drug, which also has antimalarial activity.
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Trade names | Rodilone Hansolar |
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ECHA InfoCard | 100.000.936 |
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Formula | C16H16N2O4S |
Molar mass | 332.37 g·mol−1 |
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Melting point | 290 °C (554 °F) |
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Acedapsone is the INN for diacetyldapsone. It was synthesized and developed in 1937 by Ernest Fourneau and his team in the pharmaceutical chemistry laboratory of Pasteur Institute,[1] and it was marketed as Rodilone by the Rhône-Poulenc company.[2]
It is a long-acting prodrug of dapsone. It is used for treating leprosy.[3]
It crystallises as pale yellow needles from diethyl ether, and as leaflets from dilute ethanol. It is slightly soluble in water.[citation needed]
Acedapsone is conveniently prepared by acetylation of dapsone.
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