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Medical condition From Wikipedia, the free encyclopedia
Abnormal basal metabolic rate refers to a high or low basal metabolic rate (BMR). It has numerous causes, both physiological (part of the body's normal function) and pathological (associated with disease).
Abnormal basal metabolic rate | |
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Specialty | Endocrinology |
An abnormal basal metabolic rate is not necessarily indicative of disease; a number of physiological factors can alter the BMR by influencing cellular metabolic activity.[1] For instance, males are more likely than females to have a high BMR, and in women, the BMR may rise to abnormal levels during pregnancy or lactation.[2] An individual's BMR varies greatly with age: infants and children typically have a high BMR, required for growth, while the elderly have a low BMR.[1] Tall, thin people have a higher BMR than their shorter counterparts, even with the same weight, due to the greater surface area of their skin.[3] The metabolic rate also decreases during sleep and increases in exercise, and individuals who exercise regularly have a higher BMR than those who are sedentary.[1] Environmental temperature also has an effect: the BMR is increased in both heat and cold.[3]
A common pathological cause for a high BMR is fever, since a rise in body temperature increases the rate of cellular metabolic reactions.[1] It is estimated that for every degree Fahrenheit of rise in body temperature, the BMR increases by 7 percent.[3]
Thyroid disease also has a marked effect on BMR, since thyroid hormones regulate the rate of cellular metabolism.[3] Hyperthyroidism—in which there is an increase in the production of thyroid hormones—leads to a high BMR, while hypothyroidism—in which thyroid hormones are depleted—causes a low BMR.[1]
Prolonged periods of abnormal nutrition cause an adaptive change in BMR; this helps the body to maintain a stable body weight in response to the change in food supply. In prolonged malnutrition, the BMR declines, while in prolonged overnutrition, the BMR is increased.[1] Cancer sometimes causes an increase in BMR, perhaps because the cancer cells that form tumors have a high level of metabolic activity.[1]
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