ATP12A

Potassium-transporting ATPase alpha chain 2 is a protein that in humans is encoded by the ATP12A gene.^[5][6][7][8]

ATP12A
Identifiers
Aliases	ATP12A, ATP1AL1, #945, HK, ATPase H+/K+ transporting non-gastric alpha2 subunit, H-K-ATPase
External IDs	OMIM: 182360; MGI: 1926943; HomoloGene: 68197; GeneCards: ATP12A; OMA:ATP12A - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.12|13q12.1-q12.3 Start 24,680,408 bp[1] End 24,712,472 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 56,602,525 bp[2] End 56,626,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trachea nasal epithelium olfactory zone of nasal mucosa epithelium of bronchus epithelium of nasopharynx bronchial epithelial cell testicle vulva mucosa of paranasal sinus oral cavity Top expressed in left colon seminal vesicula lip cervix skin of external ear skin of abdomen embryo skin of back left lung lobe blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding ATPase-coupled cation transmembrane transporter activity hydrolase activity ATP binding P-type sodium:potassium-exchanging transporter activity P-type potassium:proton transporter activity P-type potassium transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane basolateral plasma membrane potassium:proton exchanging ATPase complex Biological process sodium ion transport ion transport potassium ion transport potassium ion homeostasis regulation of pH establishment or maintenance of transmembrane electrochemical gradient proton transmembrane transport cellular sodium ion homeostasis cellular potassium ion homeostasis sodium ion export across plasma membrane potassium ion import across plasma membrane ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 479 192113 Ensembl ENSG00000075673 ENSMUSG00000022229 UniProt P54707 Q9Z1W8 RefSeq (mRNA) NM_001676 NM_001185085 NM_138652 RefSeq (protein) NP_001172014 NP_001667 NP_619593 Location (UCSC) Chr 13: 24.68 – 24.71 Mb Chr 14: 56.6 – 56.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H⁺/K⁺ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000075673 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022229 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "ATP12A - Potassium-transporting ATPase alpha chain 2 - Homo sapiens (Human) - ATP12A gene & protein". www.uniprot.org. Retrieved 9 April 2022.
6. "Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide".
7. Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
8. Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na⁺, K⁺-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.

External links

• Human ATP12A genome location and ATP12A gene details page in the UCSC Genome Browser.

Further reading

• Modyanov NN, Petrukhin KE, Sverdlov VE, et al. (1991). "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase". FEBS Lett. 278 (1): 91–4. doi:10.1016/0014-5793(91)80091-G. PMID 1847115.
• Yang-Feng TL, Schneider JW, Lindgren V, et al. (1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
• Shull MM, Lingrel JB (1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
• Sverdlov ED, Monastyrskaya GS, Broude NE, et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". FEBS Lett. 217 (2): 275–8. doi:10.1016/0014-5793(87)80677-4. PMID 3036582.
• Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN (1994). "Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family". FEBS Lett. 349 (1): 144–50. doi:10.1016/0014-5793(94)00655-5. PMID 8045293.
• Sverdlov VE, Kostina MB, Modyanov NN (1997). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Pestov NB, Romanova LG, Korneenko TV, et al. (1999). "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit". FEBS Lett. 440 (3): 320–4. doi:10.1016/S0014-5793(98)01483-5. PMID 9872395. S2CID 83264565.
• Pestov NB, Korneenko TV, Adams G, et al. (2002). "Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization". Am. J. Physiol., Cell Physiol. 282 (4): C907–16. doi:10.1152/ajpcell.00258.2001. PMID 11880279. S2CID 19898937.
• Reinhardt J, Kosch M, Lerner M, et al. (2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1". Am. J. Physiol. Renal Physiol. 283 (2): F335–43. doi:10.1152/ajprenal.00226.2001. PMID 12110518. S2CID 7158036.
• Takahashi Y, Sakai H, Kuragari M, et al. (2003). "Expression of ATP1AL1, a non-gastric proton pump, in human colorectum". Jpn. J. Physiol. 52 (3): 317–21. doi:10.2170/jjphysiol.52.317. PMID 12230809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li J, Codina J, Petroske E, et al. (2004). "The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function". Kidney Int. 65 (4): 1301–10. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469.
• Johansson M, Jansson T, Pestov NB, Powell TL (2004). "Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast". Placenta. 25 (6): 505–11. doi:10.1016/j.placenta.2003.11.008. PMID 15135233.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.