ASF1A

Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene.^[5][6][7]

ASF1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TEY, 2I32, 2IIJ, 2IO5, 3AAD, 5C3I
Identifiers
Aliases	ASF1A, CGI-98, CIA, HSPC146, anti-silencing function 1A histone chaperone
External IDs	OMIM: 609189; MGI: 1913653; HomoloGene: 8528; GeneCards: ASF1A; OMA:ASF1A - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.31 Start 118,894,152 bp[1] End 118,909,171 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B3 Start 53,472,853 bp[2] End 53,485,321 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte internal globus pallidus hair follicle gonad ganglionic eminence Skeletal muscle tissue of biceps brachii epithelium of nasopharynx ventricular zone Skeletal muscle tissue of rectus abdominis Top expressed in zygote primary oocyte medial ganglionic eminence secondary oocyte primitive streak genital tubercle mandibular prominence abdominal wall maxillary prominence epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding chromatin binding protein binding Cellular component nucleus nucleoplasm protein-containing complex Biological process DNA replication-dependent chromatin assembly muscle cell differentiation nucleosome assembly regulation of transcription, DNA-templated DNA repair osteoblast differentiation transcription, DNA-templated chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25842 66403 Ensembl ENSG00000111875 ENSMUSG00000019857 UniProt Q9Y294 Q9CQE6 RefSeq (mRNA) NM_014034 NM_025541 RefSeq (protein) NP_054753 NP_079817 Location (UCSC) Chr 6: 118.89 – 118.91 Mb Chr 10: 53.47 – 53.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.^[7]

Interactions

ASF1A has been shown to interact with TLK1,^[8][9] TLK2,^[8] CHAF1B^[10] and CHAF1A.^[10]