ARPC3

Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene.^[5][6][7]

ARPC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P9N, 1TYQ, 1U2V, 4JD2, 3DXK, 3UKU, 3UKR, 2P9P, 2P9K, 2P9U, 3ULE, 3RSE, 2P9S, 2P9I, 4XF2, 2P9L, 1K8K, 3DXM, 4XEI
Identifiers
Aliases	ARPC3, ARC21, p21-Arc, actin related protein 2/3 complex subunit 3
External IDs	OMIM: 604225; MGI: 1928375; HomoloGene: 4178; GeneCards: ARPC3; OMA:ARPC3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 110,434,823 bp[1] End 110,450,422 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 122,529,941 bp[2] End 122,552,247 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte appendix rectum islet of Langerhans gallbladder right lung mucosa of transverse colon olfactory zone of nasal mucosa smooth muscle tissue Top expressed in granulocyte superior surface of tongue mesenteric lymph nodes stroma of bone marrow endothelial cell of lymphatic vessel right lung lobe thymus mucous cell of stomach spleen medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding structural constituent of cytoskeleton protein binding actin binding Cellular component cytoplasm cytosol cell projection membrane focal adhesion arp2/3 protein complex actin cytoskeleton extracellular exosome cytoskeleton lamellipodium cell leading edge filamentous actin growth cone leading edge nucleus site of double-strand break Biological process Fc-gamma receptor signaling pathway involved in phagocytosis ephrin receptor signaling pathway regulation of actin filament polymerization Arp2/3 complex-mediated actin nucleation cellular response to nerve growth factor stimulus membrane organization actin polymerization-dependent cell motility Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10094 56378 Ensembl ENSG00000111229 ENSMUSG00000029465 UniProt O15145 Q9JM76 RefSeq (mRNA) NM_001287222 NM_001278556 NM_019824 RefSeq (protein) NP_001265485 NP_001274151 NP_062798 Location (UCSC) Chr 12: 110.43 – 110.45 Mb Chr 5: 122.53 – 122.55 Mb PubMed search [3] [4]
Wikidata
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ARP2/3 complex ARPC3 (21 kDa) subunit
crystal structure of arp2/3 complex with bound adp and calcium
Identifiers
Symbol	P21-Arc
Pfam	PF04062
InterPro	IPR007204
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

This gene encodes one of seven subunits of the Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.^[7]