ARL8A

ADP-ribosylation factor-like protein 8A is a protein that in humans is encoded by the ARL8A gene.^[5][6]

ARL8A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZD9, 2H18, 4ILE
Identifiers
Aliases	ARL8A, ARL10B, GIE2, ADP ribosylation factor like GTPase 8A
External IDs	OMIM: 616597; MGI: 1915974; HomoloGene: 23600; GeneCards: ARL8A; OMA:ARL8A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,133,404 bp[1] End 202,144,743 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 135,074,562 bp[2] End 135,084,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment Brodmann area 9 hypothalamus ganglionic eminence substantia nigra cingulate gyrus anterior cingulate cortex inferior ganglion of vagus nerve putamen amygdala Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell granulocyte dorsomedial hypothalamic nucleus cerebellar cortex neural layer of retina piriform cortex habenula subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding alpha-tubulin binding GTP binding protein binding beta-tubulin binding GTPase activity Cellular component cytoplasm spindle midzone lysosomal membrane endosome lysosome midbody extracellular exosome intracellular anatomical structure membrane late endosome membrane plasma membrane azurophil granule membrane ficolin-1-rich granule membrane vacuolar membrane axon cytoplasm spindle cytoskeleton cell junction axon cell projection synapse Biological process cell division small GTPase mediated signal transduction cell cycle chromosome segregation neutrophil degranulation anterograde axonal transport protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127829 68724 Ensembl ENSG00000143862 ENSMUSG00000026426 UniProt Q96BM9 Q8VEH3 RefSeq (mRNA) NM_138795 NM_001256129 NM_026823 RefSeq (protein) NP_001243058 NP_620150 NP_081099 Location (UCSC) Chr 1: 202.13 – 202.14 Mb Chr 1: 135.07 – 135.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000143862 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026426 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
6. "Entrez Gene: ARL8A ADP-ribosylation factor-like 8A".

External links

• Human ARL8A genome location and ARL8A gene details page in the UCSC Genome Browser.

Further reading

• Hofmann I, Munro S (April 2006). "An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility". Journal of Cell Science. 119 (Pt 8): 1494–503. doi:10.1242/jcs.02958. PMID 16537643.
• Okai T, Araki Y, Tada M, Tateno T, Kontani K, Katada T (September 2004). "Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation". Journal of Cell Science. 117 (Pt 20): 4705–15. doi:10.1242/jcs.01347. PMID 15331635. S2CID 24407165.
• Secombe J, Parkhurst SM (April 2004). "Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein". The Journal of Biological Chemistry. 279 (17): 17126–33. doi:10.1074/jbc.M310097200. PMID 14871887.