ARL6IP5

PRA1 family protein 3 is a protein that in humans is encoded by the ARL6IP5 gene.^[5][6][7]

ARL6IP5
Identifiers
Aliases	ARL6IP5, DERP11, GTRAP3-18, JWA, PRAF3, addicsin, hp22, jmx, HSPC127, Yip6b, ADP ribosylation factor like GTPase 6 interacting protein 5
External IDs	OMIM: 605709; MGI: 1929501; HomoloGene: 4673; GeneCards: ARL6IP5; OMA:ARL6IP5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.1 Start 69,084,937 bp[1] End 69,106,092 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D3 Start 97,187,650 bp[2] End 97,210,276 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell lateral nuclear group of thalamus visceral pleura parietal pleura right ventricle superficial temporal artery Skeletal muscle tissue of biceps brachii hair follicle pars compacta synovial joint Top expressed in ankle digastric muscle temporal muscle muscle of thigh superior frontal gyrus primary visual cortex triceps brachii muscle sternocleidomastoid muscle decidua cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cytoplasm integral component of membrane plasma membrane extracellular exosome cytoskeleton endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process negative regulation of mitochondrial membrane potential intrinsic apoptotic signaling pathway in response to oxidative stress positive regulation of cysteine-type endopeptidase activity involved in apoptotic process L-glutamate transmembrane transport positive regulation of stress-activated MAPK cascade positive regulation of apoptotic process negative regulation of L-glutamate import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10550 65106 Ensembl ENSG00000144746 ENSMUSG00000035199 UniProt O75915 Q8R5J9 RefSeq (mRNA) NM_006407 NM_022992 RefSeq (protein) NP_006398 NP_075368 Location (UCSC) Chr 3: 69.08 – 69.11 Mb Chr 6: 97.19 – 97.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.^[7] The disruption of the mouse gene results in increased neuronal glutathione content, neuroprotection against oxidative stress and a better performance in motor/spatial learning and memory tests than wild-type mice.

Interactions

ARL6IP5 has been shown to interact with SLC1A1.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000144746 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035199 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (Mar 2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature. 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046. S2CID 4622513.
6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
7. "Entrez Gene: ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5".

External links

• Human ARL6IP5 genome location and ARL6IP5 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ingley E, Williams JH, Walker CE, et al. (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Lett. 459 (1): 69–74. doi:10.1016/S0014-5793(99)01188-6. PMID 10508919. S2CID 30948975.
• Butchbach ME, Lai L, Lin CL (2002). "Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18". Gene. 292 (1–2): 81–90. doi:10.1016/S0378-1119(02)00669-8. PMID 12119102.
• Ikemoto MJ, Inoue K, Akiduki S, et al. (2003). "Identification of addicsin/GTRAP3-18 as a chronic morphine-augmented gene in amygdala". NeuroReport. 13 (16): 2079–84. doi:10.1097/00001756-200211150-00018. PMID 12438930. S2CID 43751076.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Butchbach ME, Guo H, Lin CL (2003). "Methyl-beta-cyclodextrin but not retinoic acid reduces EAAT3-mediated glutamate uptake and increases GTRAP3-18 expression". J. Neurochem. 84 (4): 891–4. doi:10.1046/j.1471-4159.2003.01588.x. PMID 12562531. S2CID 23283506.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
• Mao WG, Li AP, Ye J, et al. (2004). "[Effect of differentiation inducer and heat stress on the expression of JWA protein and Hsp70 of K562 cells]". Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 21 (4): 253–6. PMID 14761432.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Schweneker M, Bachmann AS, Moelling K (2005). "JM4 is a four-transmembrane protein binding to the CCR5 receptor". FEBS Lett. 579 (7): 1751–8. doi:10.1016/j.febslet.2005.02.037. PMID 15757671. S2CID 1173694.
• Zhu T, Chen R, Li AP, et al. (2005). "Regulation of a novel cell differentiation-associated gene, JWA during oxidative damage in K562 and MCF-7 cells". J. Biomed. Sci. 12 (1): 219–27. doi:10.1007/s11373-004-8186-4. PMID 15864752.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Huang S, Shen Q, Mao WG, et al. (2006). "JWA, a novel signaling molecule, involved in the induction of differentiation of human myeloid leukemia cells". Biochem. Biophys. Res. Commun. 341 (2): 440–50. doi:10.1016/j.bbrc.2005.12.197. PMID 16430862.
• Huang S, Shen Q, Mao WG, et al. (2006). "JWA, a novel signaling molecule, involved in all-trans retinoic acid induced differentiation of HL-60 cells". J. Biomed. Sci. 13 (3): 357–71. doi:10.1007/s11373-005-9068-0. PMID 16468075.
• Fo CS, Coleman CS, Wallick CJ, et al. (2006). "Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2)". Gene. 371 (1): 154–65. doi:10.1016/j.gene.2005.12.009. PMID 16481131.
• Aoyama K, Wang F, Matsumura N, et al. (2012). "Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice". Neurobiol Dis. 45 (3): 973–82. doi:10.1016/j.nbd.2011.12.016. PMID 22210510. S2CID 22266026.