List of AM cannabinoids

Alexandros Makriyannis is a professor in the Department of Medicinal Chemistry at Northeastern University, where his research group has synthesized many new compounds with cannabinoid activity. Some of those are:

Cannabinoids and their affinities, selectivities and structures

Name	Class	Ki / nM at CB1	Ki / nM at CB2	Selectivity	CLogP	Structure	Description
AM-087	Dibenzopyran	0.43			6.47		An analgesic CB1 agonist derived from Δ8-THC substituted with a side chain on the 3-position, roughly 100 times as potent as THC.
AM-251	Pyrazole derivative	7.5			7.08		An inverse agonist at the CB1 cannabinoid receptor that is structurally related to SR141716A (rimonabant), but has a higher binding affinity.[1]
AM-279							A Schedule I substance in Alabama.[2]
AM-281							N-(morpholin-4-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide[1]
AM-356		17.9	868		5.55		A synthetically created stable chiral analog of anandamide, it acts on both cannabinoid receptors.[3]
AM-374							Palmitylsulfonyl fluoride[4]
AM-381							Stearylsulfonyl fluoride
AM-404					7.02		An active metabolite of paracetamol (acetaminophen) and a likely inhibitor of fatty acid amide hydrolase (FAAH)
AM-411		6.80	52.0				An adamantyl-substituted derivative of Δ8-THC, it is a potent and fairly selective CB1 full agonist and a moderately potent CB2 agonist.
AM-630			32.1	CB2 (165×)	4.19		A potent and selective inverse agonist for the cannabinoid receptor CB2 and a weak partial agonist at CB1.
AM-661							1-(N-methyl-2-piperidine)methyl-2-methyl-3-(2-iodo)benzoylindole[5]
AM-678		9.00 ± 5.00	2.94 ± 2.65	CB2	5.68		Another name for JWH-018, it is a full agonist at both cannabinoid receptors with some selectivity for CB2.
AM-679		13.5	49.5		6.04		An iodobenzoylindole which acts as a moderately potent agonist for both cannabinoid receptors.
AM-694		0.08	1.44	CB1 (18×)	5.54		An iodobenzoylindole which acts as a potent and selective agonist for the CB1 cannabinoid receptor.[6]
AM-735		8.9	7.4				3-bornyl-Δ8-THC, a mixed CB1 / CB2 agonist.[7]
AM-855		22.3	58.6	CB1	7.1		An analgesic derivative of Δ8-tetrahydrocannabinol, it is an agonist at both CB1 and CB2 with moderate selectivity for CB1.
AM-881		5.3	95				A chlorine-substituted stereoisomer of anandamide.[3]
AM-883		9.9	226				An allyl-substituted stereoisomer of anandamide.[3]
AM-905		1.2	5.3	CB1	4.98		A potent and reasonably selective agonist for the CB1 cannabinoid receptor.
AM-906		0.8	9.5	CB1	4.98		A potent and dodecally selective agonist for the CB1 cannabinoid receptor.
AM-919		2.2	3.4	CB1	6.21		A potent agonist at both CB1 and CB2 with moderate selectivity for CB1. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
AM-926		2.2	4.3	CB1			A potent agonist at both CB1 and CB2 with moderate selectivity for CB1. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
AM-938		1.2	0.3	CB2 (4×)	5.92		A potent agonist at both CB1 and CB2. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
AM-1116		7.4					A dimethylated stereoisomer of anandamide.[3]
AM-1172							An endocannabinoid analog specifically designed to be a potent and selective inhibitor of AEA uptake that is resistant to FAAH hydrolysis.
AM-1220		3.88	73.4	CB1 (19×)	4.73		A potent and selective analgesic CB1 agonist (as racemate). The (R) enantiomer has around 1000× higher affinity for CB1 than (S) enantiomer.[8][9]
AM-1221		52.3	0.28	CB2 (187×)			A potent and selective CB2 agonist.
AM-1235		1.5	20.4	CB1 (13×)			A moderately CB1 selective agonist.[10]
AM-1241			3.4	CB2 (80×)			A potent and selective analgesic CB2 agonist.[11]
AM-1248				CB1			A moderately potent agonist with some selectivity for CB1, containing an unusual 3-(adamant-1-oyl) substitution on the indole ring.
AM-1710	Cannabilactone			CB2 (54×)			A CB2 selective cannabilactone.[12] Acts as a dual CB2 agonist / CB1 antagonist.[13]
AM-1714	Cannabilactone			CB2 (490×)	6.17		A CB2 selective cannabilactone.[12]
AM-1902							A nonclassical cannabinoid[14]
AM-2201		1.0	2.6	CB1	5.18		A potent agonist at both CB1 and CB2 with moderate selectivity for CB1.
AM-2212		1.4	18.9	CB1			A potent agonist at both CB1 and CB2 with dodecal selectivity for CB1.[5]
AM-2213		3.0	30	CB1 (10×)			A potent agonist at both CB1 and CB2.[5]
AM-2232		0.28	1.48		4.75		A potent agonist at both CB1 and CB2.[10]
AM-2233		1.8	2.2	CB1	5.09		The (R) enantiomer is potent and selective CB1 agonist used in 131I radiolabelled form to map distribution of CB1 receptors in brain.[15][16][17][18][19][20]
AM-2389		0.16		CB1 (26×)	6		Classical cannabinoid derivative.
AM-3102		33000	26000				An analog of oleoylethanolamide, the endogenous agonist for proliferator-activated receptor α (PPARα). It also acts as a weak cannabinoid agonist.
AM-4030		0.7	8.6	CB1 (12×)	6.17		A potent agonist at both CB1 and CB2, it is dodecally selective for CB1. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
AM-4054		2.2		CB1 (40×)			A potent but slow-onset agonist.[21][22]
AM-4056		0.041			6.51		Another name for HU-243, it is a potent agonist at both the CB1 and CB2 receptors.
AM-4113				CB1			A CB1 selective neutral antagonist.[23]
AM-6545				CB1	4.06		A peripherally selective silent antagonist of CB1 receptors.
AM-7438							A potent agonist of CB1 and CB2 with reduced duration of action.[24]
AM-11245

See also

• List of CP cannabinoids
• List of JWH cannabinoids
• List of HU cannabinoids
• List of miscellaneous designer cannabinoids