ALPI

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

ALPI

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.[5][6]

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ALPI
Identifiers
AliasesALPI, IAP, alkaline phosphatase, intestinal
External IDsOMIM: 171740; MGI: 87984; HomoloGene: 134333; GeneCards: ALPI; OMA:ALPI - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001631

NM_007432

RefSeq (protein)

NP_001622

n/a

Location (UCSC)Chr 2: 232.46 – 232.46 MbChr 1: 87.05 – 87.06 Mb
PubMed search[3][4]
Wikidata
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Intestinal alkaline phosphatase is an endogenous protein that plays an essential function in the maintenance of gut homeostasis. The protein is responsible for detoxifying bacterial toxins, dephosphorylating phosphorylated nucleotides, regulating lipid absorption in the intestine, and regulating the microbiome in the intestine.[7] In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.[8]

References

Further reading

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