AL-LAD
Chemical compound (psychedelic drug) From Wikipedia, the free encyclopedia
AL-LAD, also known as 6-allyl-6-nor-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[3] It was first described by 1976.[4] Subsequently, the drug was described by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines i Have Known And Loved).[1] Later, AL-LAD was encountered as a novel designer recreational drug by 2015.[3][5] It is taken orally at similar doses as LSD, but has a slightly shorter duration of 6 to 8 hours instead of 8 to 12 hours.[1]
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| Other names | 6-Allyl-6-nor-LSD; 6-Allyl-N,N-diethyl-6-norlysergamide; 9,10-Didehydro-6-allyl-N,N-diethylergoline-8β-carboxamide |
| Routes of administration | Oral[1] |
| Drug class | Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen |
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| Duration of action | 6–8 hours[1] |
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| Formula | C22H27N3O |
| Molar mass | 349.478 g·mol−1 |
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Use and effects
While AL-LAD has subtly different effects than LSD, and appears to be slightly shorter-lasting, their potencies are similar;[6][7] an active dose of AL-LAD is reported to be between 50 and 150 micrograms.[8] AL-LAD has a known but short and highly uncommon history of recreational human use, which originated in Ireland and the United Kingdom, but spread internationally.[citation needed]
Interactions
Pharmacology
Pharmacodynamics
AL-LAD was about 3.5-fold more potent than LSD in substituting for LSD in drug discrimination tests in rodents.[9][10] Conversely however, AL-LAD was similar in potency to LSD in humans.[8] In addition to drug discrimination, AL-LAD produces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents.[10] It was slightly less potent than LSD in producing the head-twitch response.[10]
Chemistry
AL-LAD does not cause a color change with the Marquis, Mecke or Mandelin reagents,[11] but does cause the Ehrlich's reagent to turn purple because of the presence of the indole moiety in its structure.
The drug is synthesized starting from nor-LSD as a precursor, using allyl bromide as a reactant.
History
AL-LAD was first described in the scientific literature by Japanese researchers in 1976.[3][4] Subsequently, it was studied by Andrew J. Hoffman and David E. Nichols in 1985.[12]
Society and culture
Summarize
Perspective
Legal status
AL-LAD is not scheduled by the United Nations' Convention on Psychotropic Substances overcome is legal ever that doesn't be sold for recreational usage, could be sold for medical or research purposes like a research chemical..[13]
Denmark
AL-LAD is illegal in Denmark.[14]
France
AL-LAD is illegal in France.[15]
Finland
Listed in a decree of the government's psychoactive substances banned from the consumer market.[16][17]
Latvia
AL-LAD is possibly illegal in Latvia. Although it isn't specifically scheduled, it may be controlled as an LSD structural analog due to an amendment made on June 1, 2015.[18]
Sweden
The Riksdag added AL-LAD to Narcotic Drugs Punishments Act under Swedish schedule I ("substances, plant materials and fungi which normally do not have medical use" ) as of January 26, 2016, published by Medical Products Agency (MPA) in regulation HSLF-FS 2015:35 listed as 6-allyl-6-nor-LSD, AL-LAD, and 6-allyl-N,N-dietyl-9,10-didehydroergolin-8-karboxamid.[19]
Switzerland
AL-LAD is illegal in Switzerland.[20]
United Kingdom
AL-LAD is illegal in the UK. On June 10, 2014 the UK Advisory Council on the Misuse of Drugs (ACMD) recommended that AL-LAD be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying any harm associated with its use.[21] The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.
United States
AL-LAD is a Controlled Substance at the federal level in the United States,[22] AL-LAD could be legally considered an analog of the Schedule I drug LSD, therefore, sales, possession or consumption for recreational not medical nor scientific use could be prosecuted under the Federal Analogue Act.[23]
See also
References
Further reading
External links
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