AL-38022A

AL-38022A is an indazole derivative drug which is one of a range of similar drugs developed for scientific research and with some possible clinical applications such as in the treatment of glaucoma.^[1] It acts as a potent and selective agonist for the 5-HT₂ family of serotonin receptors, with highest binding affinity for the 5-HT_2C subtype and around four times less affinity for 5-HT_2A and 5-HT_2B. In drug discrimination tests on animals, it fully substituted for both DOM and 5-MeO-DMT.^[2]

AL-38022A

Identifiers
IUPAC name (S)-2-(8,9-Dihydro-7H'-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine
CAS Number	478132-11-5 N
PubChem CID	22496603
ChemSpider	26286943 Y
UNII	76NY5U584E
CompTox Dashboard (EPA)	DTXSID40626203
Chemical and physical data
Formula	C13H17N3O
Molar mass	231.299 g·mol−1
3D model (JSmol)	Interactive image
Melting point	106 to 107 °C (223 to 225 °F)
SMILES c13CCCOc3ccc(cn2)c1n2CC(C)N
InChI InChI=1S/C13H17N3O/c1-9(14)8-16-13-10(7-15-16)4-5-12-11(13)3-2-6-17-12/h4-5,7,9H,2-3,6,8,14H2,1H3/t9-/m0/s1 Y Key:FJRIVFVALIEIOY-VIFPVBQESA-N Y
NY (what is this?)  (verify)

See also

• AL-34662
• AL-37350A
• Ro60-0175
• VER-3323
• YM-348

References

1. Chen HH, May JA, Severns BS. Pyranoindazoles and their use for the treatment of glaucoma. US 6881749
2. May JA, Sharif NA, Chen HH, Liao JC, Kelly CR, Glennon RA, et al. (January 2009). "Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]". Pharmacology, Biochemistry, and Behavior. 91 (3): 307–14. doi:10.1016/j.pbb.2008.07.015. PMC 3763814. PMID 18718483.