AKAP1

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.^[5][6][7]

AKAP1
Identifiers
Aliases	AKAP1, AKAP, AKAP121, AKAP149, AKAP84, D-PPP1R43, PRKA1, SAKAP84, TDRD17, A-kinase anchoring protein 1
External IDs	OMIM: 602449; MGI: 104729; HomoloGene: 31165; GeneCards: AKAP1; OMA:AKAP1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 57,085,092 bp[1] End 57,121,346 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 88,721,618 bp[2] End 88,755,412 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm body of tongue Skeletal muscle tissue of rectus abdominis left testis thoracic diaphragm right testis cardia saphenous vein vena cava Top expressed in seminiferous tubule spermatid neural layer of retina brown adipose tissue digastric muscle right ventricle soleus muscle extraocular muscle primary oocyte thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase A regulatory subunit binding nucleic acid binding RNA binding Cellular component integral component of membrane mitochondrion mitochondrial outer membrane membrane cytosol Biological process regulation of protein kinase A signaling blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8165 11640 Ensembl ENSG00000121057 ENSMUSG00000018428 UniProt Q92667 O08715 RefSeq (mRNA) NM_001242902 NM_001242903 NM_003488 NM_139275 NM_001370423 NM_001370424 NM_001370425 NM_001370426 NM_001370427 NM_001042541 NM_009648 RefSeq (protein) NP_001229831 NP_001229832 NP_003479 NP_001357352 NP_001357353 NP_001357354 NP_001357355 NP_001357356 NP_001036006 NP_033778 Location (UCSC) Chr 17: 57.09 – 57.12 Mb Chr 11: 88.72 – 88.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.^[7]

Interactions

AKAP1 has been shown to interact with:

• C3orf15,^[8]
• MYCBP,^[8][9]
• PRKAR1A,^[10][11]
• PRKAR1B,^[10] and
• PRKAR2A.^[11][12]

References

1. GRCh38: Ensembl release 89: ENSG00000121057 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018428 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Trendelenburg G, Hummel M, Riecken EO, Hanski C (Sep 1996). "Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain". Biochem Biophys Res Commun. 225 (1): 313–9. doi:10.1006/bbrc.1996.1172. PMID 8769136.
6. Lin RY, Moss SB, Rubin CS (Jan 1996). "Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells". J Biol Chem. 270 (46): 27804–11. doi:10.1074/jbc.270.46.27804. PMID 7499250.
7. "Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1".
8. Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483.
9. Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. doi:10.1074/jbc.M103885200. PMID 11483602.
10. Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
11. Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K (April 2000). "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. doi:10.1006/jmbi.2000.3662. PMID 10764601.
12. Kapiloff MS, Schillace RV, Westphal AM, Scott JD (Aug 1999). "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes". J. Cell Sci. 112 (16): 2725–36. doi:10.1242/jcs.112.16.2725. PMID 10413680.

External links

• Human AKAP1 genome location and AKAP1 gene details page in the UCSC Genome Browser.

Further reading

• Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
• Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
• Huang LJ, Durick K, Weiner JA, et al. (1997). "Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits". J. Biol. Chem. 272 (12): 8057–64. doi:10.1074/jbc.272.12.8057. PMID 9065479.
• Huang LJ, Wang L, Ma Y, et al. (1999). "NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum". J. Cell Biol. 145 (5): 951–9. doi:10.1083/jcb.145.5.951. PMC 2133123. PMID 10352013.
• Herberg FW, Maleszka A, Eide T, et al. (2000). "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. doi:10.1006/jmbi.2000.3662. PMID 10764601.
• Steen RL, Martins SB, Taskén K, Collas P (2000). "Recruitment of Protein Phosphatase 1 to the Nuclear Envelope by a-Kinase Anchoring Protein Akap149 Is a Prerequisite for Nuclear Lamina Assembly". J. Cell Biol. 150 (6): 1251–62. doi:10.1083/jcb.150.6.1251. PMC 2150688. PMID 10995432.
• Furusawa M, Ohnishi T, Taira T, et al. (2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. doi:10.1074/jbc.M103885200. PMID 11483602.
• Razani B, Lisanti MP (2001). "Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A". Am. J. Physiol., Cell Physiol. 281 (4): C1241–50. doi:10.1152/ajpcell.2001.281.4.C1241. PMID 11546661. S2CID 34190425.
• Yukitake H, Furusawa M, Taira T, et al. (2003). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483.
• Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. doi:10.1074/jbc.M206387200. PMID 12414807.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Carlson CR, Ruppelt A, Taskén K (2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
• Steen RL, Beullens M, Landsverk HB, et al. (2004). "AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase". J. Cell Sci. 116 (Pt 11): 2237–46. doi:10.1242/jcs.00432. PMID 12697839.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Cardone L, Carlucci A, Affaitati A, et al. (2004). "Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1, a Novel Positive Regulator of src Signaling". Mol. Cell. Biol. 24 (11): 4613–26. doi:10.1128/MCB.24.11.4613-4626.2004. PMC 416429. PMID 15143158.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.