ADCY9

Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene.^[5][6]

ADCY9
Identifiers
Aliases	ADCY9, AC9, ACIX, adenylate cyclase 9
External IDs	OMIM: 603302; MGI: 108450; HomoloGene: 868; GeneCards: ADCY9; OMA:ADCY9 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 3,953,387 bp[1] End 4,116,442 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 2.42 cM Start 4,105,393 bp[2] End 4,238,362 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Epithelium of choroid plexus vastus lateralis muscle myocardium of left ventricle gastrocnemius muscle glutes Skeletal muscle tissue of biceps brachii parotid gland deltoid muscle endothelial cell Top expressed in CA3 field Region I of hippocampus proper triceps brachii muscle sternocleidomastoid muscle temporal muscle primary motor cortex dentate gyrus vastus lateralis muscle Rostral migratory stream subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding lyase activity phosphorus-oxygen lyase activity ATP binding adenylate cyclase activity guanylate cyclase activity Cellular component membrane integral component of plasma membrane axon dendrite plasma membrane integral component of membrane guanylate cyclase complex, soluble intracellular anatomical structure Biological process intracellular signal transduction cellular response to glucagon stimulus cyclic nucleotide biosynthetic process adenylate cyclase-activating adrenergic receptor signaling pathway renal water homeostasis signal transduction cAMP biosynthetic process adenylate cyclase-activating G protein-coupled receptor signaling pathway cGMP biosynthetic process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway activation of adenylate cyclase activity activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115 11515 Ensembl ENSG00000162104 ENSMUSG00000005580 UniProt O60503 P51830 RefSeq (mRNA) NM_001116 NM_001291910 NM_009624 RefSeq (protein) NP_001107 NP_001278839 NP_033754 Location (UCSC) Chr 16: 3.95 – 4.12 Mb Chr 16: 4.11 – 4.24 Mb PubMed search [3] [4]
Wikidata
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Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.^[6]