Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.[5][6][7]
Quick Facts Available structures, PDB ...
ABI2 |
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Identifiers |
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Aliases | ABI2, ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB, abl-interactor 2, abl interactor 2, AIP1 |
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External IDs | OMIM: 606442; MGI: 106913; HomoloGene: 4209; GeneCards: ABI2; OMA:ABI2 - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Brodmann area 23
- entorhinal cortex
- middle temporal gyrus
- postcentral gyrus
- external globus pallidus
- internal globus pallidus
- superior frontal gyrus
- superior vestibular nucleus
- ventral tegmental area
- lateral nuclear group of thalamus
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| Top expressed in | - lateral septal nucleus
- olfactory tubercle
- anterior amygdaloid area
- primary motor cortex
- ventromedial nucleus
- piriform cortex
- Region I of hippocampus proper
- cingulate gyrus
- subiculum
- nucleus accumbens
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| More reference expression data |
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BioGPS | |
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Wikidata |
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Close
ABI2 has been shown to interact with ABL1,[5][8] ADAM19,[9] and TRIM32.[10]
Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (September 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
- Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
- Wang B, Mysliwiec T, Krainc D, et al. (1996). "Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene". Oncogene. 12 (9): 1921–9. PMID 8649853.
- Juang JL, Hoffmann FM (1999). "Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity". Oncogene. 18 (37): 5138–47. doi:10.1038/sj.onc.1202911. PMID 10498863.
- Chen B, Borinstein SC, Gillis J, et al. (2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes". J. Biol. Chem. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458.
- Machado RD, Pauciulo MW, Fretwell N, et al. (2001). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
- Courtney KD, Grove M, Vandongen H, et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system". Mol. Cell. Neurosci. 16 (3): 244–57. doi:10.1006/mcne.2000.0865. PMID 10995551. S2CID 7370589.
- Stradal T, Courtney KD, Rottner K, et al. (2001). "The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia". Curr. Biol. 11 (11): 891–5. Bibcode:2001CBio...11..891S. doi:10.1016/S0960-9822(01)00239-1. PMID 11516653. S2CID 1861695.
- Huang L, Feng L, Yang L, et al. (2003). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. S2CID 22611084.
- Mammalian Gene Collection Program Team, Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cao C, Leng Y, Li C, Kufe D (2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Eastman SW, Martin-Serrano J, Chung W, et al. (2005). "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding". J. Biol. Chem. 280 (1): 628–36. doi:10.1074/jbc.M410384200. PMID 15509564.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Luo X, Levens E, Williams RS, Chegini N (2006). "The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta". Hum. Reprod. 21 (6): 1380–6. doi:10.1093/humrep/del011. PMID 16488906.
- Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133. S2CID 20005197.
- Li Y, Clough N, Sun X, et al. (2007). "BCR-ABL Induces Abnormal Cytoskeleton Remodeling, β1 Integrin Clustering, and Increased Cell Adhesion to Fibronectin Through ABL Interactor 1 Pathway". J. Cell Sci. 120 (Pt 8): 1436–46. doi:10.1242/jcs.03430. PMC 1950936. PMID 17389688.