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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ABCB8 gene.[5][6]
ABCB8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ABCB8, EST328128, M-ABC1, MABC1, ATP binding cassette subfamily B member 8, MITOSUR | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605464; MGI: 1351667; HomoloGene: 5203; GeneCards: ABCB8; OMA:ABCB8 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.[6]
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