Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.[5][6][7]
Quick Facts Identifiers, Aliases ...
AATK |
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Identifiers |
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Aliases | AATK, AATYK, AATYK1, LMR1, LMTK1, PPP1R77, p35BP, apoptosis-associated tyrosine kinase, aatyk1, mKIAA0641, apoptosis associated tyrosine kinase |
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External IDs | OMIM: 605276; MGI: 1197518; HomoloGene: 74861; GeneCards: AATK; OMA:AATK - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - sural nerve
- C1 segment
- inferior ganglion of vagus nerve
- olfactory bulb
- trigeminal ganglion
- right hemisphere of cerebellum
- subthalamic nucleus
- right frontal lobe
- ventral tegmental area
- putamen
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| Top expressed in | - perirhinal cortex
- entorhinal cortex
- primary visual cortex
- CA3 field
- superior frontal gyrus
- cerebellar cortex
- dentate gyrus of hippocampal formation granule cell
- central gray substance of midbrain
- superior colliculus
- nucleus of stria terminalis
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| More reference expression data |
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BioGPS | |
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Wikidata |
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The gene was identified in 1998. It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs. The protein is composed of 1,207 amino acids.[5][6]
The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells.[7][8]
Its suppressive role on melanoma development has been reported recently.[9]
AATK is thought to indirectly inhibit the SPAK/WNK4 activation of the Na-K-Cl cotransporter.[10]
Gagnon KB, England R, Diehl L, Delpire E (May 2007). "Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation". American Journal of Physiology. Cell Physiology. 292 (5): C1809–C1815. doi:10.1152/ajpcell.00580.2006. PMID 17267545. S2CID 10258460.
- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Raghunath M, Patti R, Bannerman P, Lee CM, Baker S, Sutton LN, Phillips PC, Damodar Reddy C (May 2000). "A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line". Brain Research. Molecular Brain Research. 77 (2): 151–62. doi:10.1016/S0169-328X(00)00048-6. PMID 10837911.
- Tomomura M, Hasegawa Y, Hashikawa T, Tomomura A, Yuzaki M, Furuichi T, Yano R (Apr 2003). "Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain". Brain Research. Molecular Brain Research. 112 (1–2): 103–12. doi:10.1016/S0169-328X(03)00054-8. PMID 12670708.
- Honma N, Asada A, Takeshita S, Enomoto M, Yamakawa E, Tsutsumi K, Saito T, Satoh T, Itoh H, Kaziro Y, Kishimoto T, Hisanaga S (Oct 2003). "Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein". Biochemical and Biophysical Research Communications. 310 (2): 398–404. doi:10.1016/j.bbrc.2003.08.143. PMID 14521924.
- Piechotta K, Garbarini N, England R, Delpire E (Dec 2003). "Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase". The Journal of Biological Chemistry. 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID 14563843.