5F-PCN

5F-PCN (also known as 5F-MN-21) is an azaindole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.^[1][2] It is closely related to NNE1. Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-PCN may release 1-naphthylamine, a known carcinogen.

5F-PCN

Legal status
Legal status	CA: Schedule II UK: Class B
Identifiers
IUPAC name 1-(5-fluoropentyl)-N-(naphthalen-1-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide
CAS Number	2219332-48-4 Y
PubChem CID	125181244
ChemSpider	34450856
UNII	Q7GH2GGJ3E
CompTox Dashboard (EPA)	DTXSID901032641
Chemical and physical data
Formula	C23H22FN3O
Molar mass	375.447 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(NC1=C(C=CC=C2)C2=CC=C1)C3=CN(CCCCCF)C4=C3C=NC=C4
InChI InChI=1S/C23H22FN3O/c24-12-4-1-5-14-27-16-20(19-15-25-13-11-22(19)27)23(28)26-21-10-6-8-17-7-2-3-9-18(17)21/h2-3,6-11,13,15-16H,1,4-5,12,14H2,(H,26,28) Key:BRRZRRZUERBDQL-UHFFFAOYSA-N

Legal status

Sweden's public health agency suggested to classify 5F-PCN as hazardous substance on November 10, 2014.^[3]

See also

• 5F-NNE1
• AM-2201
• APICA
• CUMYL-PICA
• CUMYL-5F-P7AICA
• JWH-018
• NM-2201
• SDB-005

References

1. "5F-PCN". Cayman Chemical. Retrieved 22 July 2015.
2. Blaazer AR, Lange JH, van der Neut MA, Mulder A, den Boon FS, Werkman TR, et al. (October 2011). "Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: design, synthesis, structure-activity relationships, physicochemical properties and biological activity". European Journal of Medicinal Chemistry. 46 (10): 5086–98. doi:10.1016/j.ejmech.2011.08.021. PMID 21885167.
3. "Cannabinoider föreslås bli klassade som hälsofarlig vara". Folkhälsomyndigheten. Retrieved 22 July 2015.