Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.[5][6][7]
Quick Facts Available structures, PDB ...
TP53BP1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG |
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Identifiers |
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Aliases | TP53BP1, 53BP1, p202, p53BP1, TP53, TDRD30, tumor protein p53 binding protein 1 |
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External IDs | OMIM: 605230; MGI: 1351320; HomoloGene: 4137; GeneCards: TP53BP1; OMA:TP53BP1 - orthologs |
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Wikidata |
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53BP1 is underexpressed in most cases of triple-negative breast cancer.[8]
DNA double-strand breaks (DSBs) are cytotoxic damages that can be repaired either by the homologous recombinational repair (HR) pathway or by the non-homologous end-joining (NHEJ) pathway. NHEJ, although faster than HR, is less accurate. The early divergent step between the two pathways is end resection, and this step is regulated by numerous factors. In particular, BRCA1 and 53BP1 play a role in determining the balance between the two pathways.[9][10] 53BP1 restricts resection and promotes NHEJ.
53BP1 has been shown to physically interact with:
Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J (Jun 2010). "53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers". Nature Structural & Molecular Biology. 17 (6): 688–95. doi:10.1038/nsmb.1831. PMC 2912507. PMID 20453858.
Derbyshire DJ, Basu BP, Date T, Iwabuchi K, Doherty AJ (Oct 2002). "Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor". Acta Crystallographica Section D. 58 (Pt 10 Pt 2): 1826–9. Bibcode:2002AcCrD..58.1826D. doi:10.1107/S0907444902010910. PMID 12351827.
- Choubey D, Lengyel P (Mar 1995). "Binding of an interferon-inducible protein (p202) to the retinoblastoma protein". The Journal of Biological Chemistry. 270 (11): 6134–40. doi:10.1074/jbc.270.11.6134. PMID 7890747.
- Choubey D, Li SJ, Datta B, Gutterman JU, Lengyel P (Oct 1996). "Inhibition of E2F-mediated transcription by p202". The EMBO Journal. 15 (20): 5668–78. doi:10.1002/j.1460-2075.1996.tb00951.x. PMC 452311. PMID 8896460.
- Datta B, Li B, Choubey D, Nallur G, Lengyel P (Nov 1996). "p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition". The Journal of Biological Chemistry. 271 (44): 27544–55. doi:10.1074/jbc.271.44.27544. PMID 8910340.
- Wen Y, Yan DH, Spohn B, Deng J, Lin SY, Hung MC (Jan 2000). "Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells". Cancer Research. 60 (1): 42–6. PMID 10646849.
- Xia Z, Morales JC, Dunphy WG, Carpenter PB (Jan 2001). "Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1". The Journal of Biological Chemistry. 276 (4): 2708–18. doi:10.1074/jbc.M007665200. PMID 11042216.
- Joo WS, Jeffrey PD, Cantor SB, Finnin MS, Livingston DM, Pavletich NP (Mar 2002). "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure". Genes & Development. 16 (5): 583–93. doi:10.1101/gad.959202. PMC 155350. PMID 11877378.
- Derbyshire DJ, Basu BP, Serpell LC, Joo WS, Date T, Iwabuchi K, Doherty AJ (Jul 2002). "Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor". The EMBO Journal. 21 (14): 3863–72. doi:10.1093/emboj/cdf383. PMC 126127. PMID 12110597.
- Lai H, Lin L, Nadji M, Lai S, Trapido E, Meng L (2002). "Mutations in the p53 tumor suppressor gene and early onset breast cancer". Cancer Biology & Therapy. 1 (1): 31–6. doi:10.4161/cbt.1.1.37. PMID 12170762.
- Derbyshire DJ, Basu BP, Date T, Iwabuchi K, Doherty AJ (Oct 2002). "Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor". Acta Crystallographica Section D. 58 (Pt 10 Pt 2): 1826–9. Bibcode:2002AcCrD..58.1826D. doi:10.1107/S0907444902010910. PMID 12351827.
- Wang B, Matsuoka S, Carpenter PB, Elledge SJ (Nov 2002). "53BP1, a mediator of the DNA damage checkpoint". Science. 298 (5597): 1435–8. Bibcode:2002Sci...298.1435W. doi:10.1126/science.1076182. PMID 12364621. S2CID 30076227.
- Richie CT, Peterson C, Lu T, Hittelman WN, Carpenter PB, Legerski RJ (Dec 2002). "hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage". Molecular and Cellular Biology. 22 (24): 8635–47. doi:10.1128/MCB.22.24.8635-8647.2002. PMC 139863. PMID 12446782.
- DiTullio RA, Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, Halazonetis TD (Dec 2002). "53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer". Nature Cell Biology. 4 (12): 998–1002. doi:10.1038/ncb892. PMID 12447382. S2CID 7430614.
- Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A (Dec 2002). "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1". Nature Cell Biology. 4 (12): 993–7. doi:10.1038/ncb884. PMID 12447390. S2CID 12380387.
- Peng A, Chen PL (Mar 2003). "NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage". The Journal of Biological Chemistry. 278 (11): 8873–6. doi:10.1074/jbc.C300001200. PMID 12551934.
- Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ (Feb 2003). "MDC1 is a mediator of the mammalian DNA damage checkpoint". Nature. 421 (6926): 961–6. Bibcode:2003Natur.421..961S. doi:10.1038/nature01446. PMID 12607005. S2CID 4410773.
- Yan DH, Abramian A, Li Z, Ding Y, Wen Y, Liu TJ, Hunt K (Mar 2003). "P202, an interferon-inducible protein, inhibits E2F1-mediated apoptosis in prostate cancer cells". Biochemical and Biophysical Research Communications. 303 (1): 219–22. doi:10.1016/S0006-291X(03)00320-6. PMID 12646190.
- Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ (Mar 2003). "Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response". The Journal of Cell Biology. 160 (7): 1017–27. doi:10.1083/jcb.200209065. PMC 2172769. PMID 12668657.
- Caldwell RB, Braselmann H, Schoetz U, Heuer S, Scherthan H, Zitzelsberger H (July 4, 2016). "Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells". Sci. Rep. 6: 28890. Bibcode:2016NatSR...628890C. doi:10.1038/srep28890. PMC 4931448. PMID 27374870.
- Overview of all the structural information available in the PDB for UniProt: Q12888 (TP53-binding protein 1) at the PDBe-KB.