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Niels Vink defeated Sam Schröder in the final, 7–5, 6–3 to win the quad singles wheelchair tennis title at the 2022 US Open. It was his first US Open singles title and second major singles title overall.
| Wheelchair quad singles | |
|---|---|
| 2022 US Open | |
| Champion |  Niels Vink |
| Runner-up | Sam Schröder |
| Score | 7–5, 6–3 |
Dylan Alcott was the reigning champion,[1] but retired from professional wheelchair tennis in January 2022.[2]
Niels Vink (champion)- Sam Schröder (final)
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals
| Quarterfinals | Semifinals | Final | ||||||||||||||||||
| 1 | Niels Vink
| 6 | 6 | |||||||||||||||||
| WC |  Robert Shaw
| 2 | 0 | |||||||||||||||||
| 1 | Niels Vink
| 6 | 6 | |||||||||||||||||
 Donald Ramphadi
| 1 | 1 | ||||||||||||||||||
 Koji Sugeno
| 6 | 3 | 5 | |||||||||||||||||
| Donald Ramphadi
| 2 | 6 | 7 | |||||||||||||||||
| 1 | Niels Vink
| 7 | 6 | |||||||||||||||||
| 2 | Sam Schröder
| 5 | 3 | |||||||||||||||||
 Andy Lapthorne
| 6 | 1 | 2 | |||||||||||||||||
 David Wagner
| 4 | 6 | 6 | |||||||||||||||||
| David Wagner
| 0 | 63 | ||||||||||||||||||
| 2 | Sam Schröder
| 6 | 77 | |||||||||||||||||
 Heath Davidson
| 6 | 63 | 3 | |||||||||||||||||
| 2 | Sam Schröder
| 3 | 77 | 6 | ||||||||||||||||
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