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The 2021 Karlsruhe Open (also known as the Liqui Moly Open for sponsorship reasons) was a professional tennis tournament played on outdoor clay courts. It was the 2nd edition of the tournament and part of the 2021 WTA 125K series, offering a total of $115,000 in prize money. It took place in Karlsruhe, Germany between 7 and 12 September 2021. The tournament did not take place in 2020 due to the COVID-19 pandemic.[1]
| 2021 Karlsruhe Open | |
|---|---|
| Date | 7 – 12 September |
| Edition | 2nd |
| Category | WTA 125K series |
| Draw | 32S / 8D |
| Prize money | $115,000 |
| Surface | Clay |
| Location | Karlsruhe, Germany |
| Venue | TC Rüppurr |
| Champions | |
| Singles | |
 Mayar Sherif | |
| Doubles | |
 Irina Bara /  Ekaterine Gorgodze | |
Singles
Mayar Sherif def. 
Martina Trevisan, 6–3, 6–2
Doubles
Irina Bara / 
Ekaterine Gorgodze def. 
Katarzyna Piter / Mayar Sherif, 6–3, 2–6, [10–7]
Seeds
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 FRA |
Clara Burel | 92 | 1 |
 SVK |
Anna Karolína Schmiedlová | 93 | 2 |
| EGY |
Mayar Sherif | 96 | 3 |
 ITA |
Martina Trevisan | 106 | 4 |
 SLO |
Kaja Juvan | 109 | 5 |
 BEL |
Maryna Zanevska | 113 | 6 |
 AUS |
Astra Sharma | 114 | 7 |
| ROU |
Irina Bara | 118 | 8 |
- 1 Rankings as of 30 August 2021.
Other entrants
The following players received a wildcard into the singles main draw:
Sina Herrmann- Tatjana Maria
- Nastasja Schunk
- Alexandra Vecic
The following players qualified into the singles main draw:
Withdrawals
- Before the tournament
- Ana Bogdan → replaced by
Maddison Inglis - Elisabetta Cocciaretto → replaced by Jaqueline Cristian
Varvara Gracheva → replaced by 
Paula Ormaechea
Polona Hercog → replaced by Ekaterine Gorgodze
Kristína Kučová → replaced by Rebecca Šramková
Varvara Lepchenko → replaced by Grace Min- Jasmine Paolini → replaced by Lucia Bronzetti
Nuria Párrizas Díaz → replaced by 
Katarina Zavatska
Kristýna Plíšková → replaced by Tamara Korpatsch
Arantxa Rus → replaced by Anastasia Gasanova- Elena-Gabriela Ruse → replaced by
Dalma Gálfi 
Viktoriya Tomova → replaced by Cristina Bucșa
Zhang Shuai → replaced by Katarzyna Kawa
Seeds
| Country | Player | Country | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| AUS |
Astra Sharma |  NED |
Rosalie van der Hoek | 218 | 1 |
 GER |
Vivian Heisen | BEL |
Kimberley Zimmermann | 232 | 2 |
 POL |
Katarzyna Piter | EGY |
Mayar Sherif | 271 | 3 |
| ROU |
Irina Bara | GEO |
Ekaterine Gorgodze | 286 | 4 |
- 1 Rankings as of 30 August 2021.
Other entrants
The following pair received a wildcard into the doubles main draw:
- Nastasja Schunk / Alexandra Vecic
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