The 1991 Copa InterAmericana was the 14th. edition of the Copa Interamericana. The final was contested by Mexican Club Puebla (winner of 1991 CONCACAF Champions' Cup) and Chilean club Colo-Colo (champion of 1991 Copa Libertadores). The final was played under a two-leg format in September 1992.
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The first leg was held in Estadio Olímpico in Villahermosa, where Colo-Colo easily beat Puebla 4–1. The second leg was played at Estadio Monumental David Arellano in Santiago, with another Colo-Colo win over Puebla (3–1). With two wins and a 7–2 aggregate score, the Chilean side won their first Interamericana trophy.[2][3][4]