March 4 –Alexander S. Wolcott and John Johnson open their "Daguerreian Parlor" on Broadway (Manhattan), the world's first commercial photography portrait studio.
May 7 – The Great Natchez Tornado: A massive tornado strikes Natchez, Mississippi during the early afternoon hours. Before it is over, 317 people are killed and 109 injured. It is the second deadliest tornado in U.S. history.