This article contains information about the literary events and publications of 1622.
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- January 6 (probably) – The Banqueting House, Whitehall, London, is opened with a performance of Ben Jonson's The Masque of Augurs designed by the building's architect, Inigo Jones.
- March 12 – Teresa of Ávila (died 1582), devotional writer, is canonized by Pope Gregory XV.
- June – Lucas Holstenius arrives in Britain to gather material for his Geographi Minores.[1]
- November 19 – English writer and politician Sir Percy Herbert, created a baronet three days earlier, marries Elizabeth Craven, daughter of William Craven, a former Lord Mayor of London.
- unknown dates
- January 15 – Molière (Jean-Baptiste Poquelin), French dramatist (died 1673)
- February 24 – Johannes Clauberg, German philosopher and theologian (died 1655)
- March 28 – Ermes di Colorêt, Italian nobleman and writer (died 1692)
- April 11 – Jan van Vliet, Dutch philologist (died 1666)
- April 17 – Henry Vaughan (died 1695), Welsh poet writing in English, and Thomas Vaughan, Welsh philosopher (died 1666, twins)
- September 22 – Jacques Savary, French commercial economist (died 1690)
- December 24 (baptised) – Francesc Fontanella, Catalan poet and dramatist (died c. 1680)
- Unknown date – Gilbert Mabbot, English journalist and licenser of the press 1647–49 (died c. 1670)
- April 14 – Antoine de Gaudier, French theologian (born 1572)
- June 4 – Péter Révay, Hungarian nobleman, poet and historian (born 1568)
- August 21 – Juan de Tassis y Peralta, 2nd Count of Villamediana, Spanish poet (murdered, born 1582)
- October – Sir George Buck, English antiquary and historian (born 1560)
- October 11 – Conrad Vetter, German polemicist (born 1547)
- November 4 – Francisco Rodrigues Lobo, Portuguese poet and bucolic writer (born 1580)
- December 19 – Benedetto Justiniani, Italian theologian (born 1550)
- Probable year of death